Document Detail

Does Hürthle Cell Carcinoma of the Thyroid Have a Poorer Prognosis than Ordinary Follicular Thyroid Carcinoma?
MedLine Citation:
PMID:  23616135     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hürthle cell carcinoma (HCC) is a rare form of thyroid carcinoma and is considered an oxyphilic variant of follicular thyroid carcinoma. However, little is known about its biological characteristics or clinical behavior. We conducted a retrospective study to determine whether the prognosis of HCC differs from that of ordinary follicular thyroid carcinoma (OFC). METHODS: The subjects were the 558 patients with follicular thyroid carcinoma who underwent initial surgery at our institution between 1989 and 2010 and consisted of 73 patients with HCC and 485 patients with OFC. There were 410 females and 148 males, and their median age was 51 years. A univariate analysis was conducted in relation to cumulative cause-specific survival (CSS) according to the Kaplan-Meier method for the following variables: age at the time of initial surgery, gender, tumor size, invasiveness, distant metastasis at presentation, and histological type (HCC vs OFC). Differences between groups were analyzed for significance by the log-rank test. Multivariate analysis was performed by using the Cox proportional hazard model. RESULTS: A total of 4 patients (5.5 %) in the HCC group had distant metastasis compared with 106 patients (21.9 %) in the OFC group. Significant factors in relation to CSS in the univariate analyses were age, tumor size, and invasiveness, but there were no significant differences between the HCC group and the OFC group. Multivariate analysis showed that age, tumor size, and distant metastasis at presentation were significant factors. CONCLUSIONS: HCC does not have a poorer prognosis than OFC.
Kiminori Sugino; Kaori Kameyama; Koichi Ito; Mitsuji Nagahama; Wataru Kitagawa; Hiroshi Shibuya; Keiko Ohkuwa; Takashi Uruno; Junko Akaishi; Akifumi Suzuki; Chie Masaki; Kunihiko Ito
Related Documents :
6328995 - Prognostic significance of histologic classification and grading of epithelial malignan...
24565955 - Serum biomarkers of bone metabolism in castration-resistant prostate cancer patients wi...
24222185 - Prognostic impact of ndrg2 and ndrg3 in prostate cancer patients undergoing radical pro...
23221605 - Prognostic role of hormone receptors in ovarian cancer: a systematic review and meta-an...
8085975 - Cea reduction after cryotherapy for liver metastases from colon cancer predicts survival.
2111415 - Prospective randomized controlled study on bestatin in resectable gastric cancer--third...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-26
Journal Detail:
Title:  Annals of surgical oncology     Volume:  -     ISSN:  1534-4681     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgery, Ito Hospital, Tokyo, Japan,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endoscopic snare papillectomy: a possible radical treatment for a subgroup of T1 ampullary adenocarc...
Next Document:  Profiles of sex steroids, fecundity and spawning of a migratory characiform fish from the Paraguay-P...