Document Detail

Does CPAP treatment in mild obstructive sleep apnea affect blood pressure?
MedLine Citation:
PMID:  20719563     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Obstructive sleep apnea (OSA) is associated with significant cardiovascular (CV) morbidity. Continuous positive airway pressure (CPAP) is the standard treatment for moderate to severe OSA, resulting in a reduction in CV morbidity. No studies have compared CV outcomes between CPAP and no CPAP in mild OSA (5>or=AHI<15).
METHODS: Retrospective cohort study of subjects (age>or=18) with mild OSA diagnosed between 2004 and 2006. Subjects with a history of hypertension, angina, stroke and smoking were excluded. Subjects were stratified into two groups: CPAP (n=93) or no CPAP (n=162). The mean blood pressures (MBP) were compared 2 years after the diagnosis of OSA was established.
RESULTS: Unmatched for covariates (age, sex, BMI, neck circumference, AHI, arousal index and family h/o CV disorders), subjects with mild OSA on CPAP had a 1.97 point reduction, and no CPAP resulted in a 9.61 point elevation (p<0.0001) in MBP. With propensity score matching for covariates, the mean difference in MBP was -1.97 (95% CI: -14.03, -9.92; p<0.0001) with a sensitivity analysis of 2.646.
CONCLUSION: This study shows an elevation of the MBP in mild OSA patients who were not treated with CPAP. CPAP treatment in mild OSA patients decreased the MBP over a 2-year period.
Nattapong Jaimchariyatam; Carlos L Rodriguez; Kumar Budur
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Publication Detail:
Type:  Journal Article     Date:  2010-08-16
Journal Detail:
Title:  Sleep medicine     Volume:  11     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
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MeSH Terms
Age Factors
Blood Pressure* / physiology
Body Mass Index
Continuous Positive Airway Pressure*
Logistic Models
Multivariate Analysis
Odds Ratio
Regression Analysis
Retrospective Studies
Sex Factors
Sleep / physiology
Sleep Apnea, Obstructive / physiopathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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