| Does CPAP treatment in mild obstructive sleep apnea affect blood pressure? | |
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MedLine Citation:
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PMID: 20719563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Obstructive sleep apnea (OSA) is associated with significant cardiovascular (CV) morbidity. Continuous positive airway pressure (CPAP) is the standard treatment for moderate to severe OSA, resulting in a reduction in CV morbidity. No studies have compared CV outcomes between CPAP and no CPAP in mild OSA (5>or=AHI<15). METHODS: Retrospective cohort study of subjects (age>or=18) with mild OSA diagnosed between 2004 and 2006. Subjects with a history of hypertension, angina, stroke and smoking were excluded. Subjects were stratified into two groups: CPAP (n=93) or no CPAP (n=162). The mean blood pressures (MBP) were compared 2 years after the diagnosis of OSA was established. RESULTS: Unmatched for covariates (age, sex, BMI, neck circumference, AHI, arousal index and family h/o CV disorders), subjects with mild OSA on CPAP had a 1.97 point reduction, and no CPAP resulted in a 9.61 point elevation (p<0.0001) in MBP. With propensity score matching for covariates, the mean difference in MBP was -1.97 (95% CI: -14.03, -9.92; p<0.0001) with a sensitivity analysis of 2.646. CONCLUSION: This study shows an elevation of the MBP in mild OSA patients who were not treated with CPAP. CPAP treatment in mild OSA patients decreased the MBP over a 2-year period. |
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Authors:
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Nattapong Jaimchariyatam; Carlos L Rodriguez; Kumar Budur |
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Publication Detail:
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Type: Journal Article Date: 2010-08-16 |
Journal Detail:
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Title: Sleep medicine Volume: 11 ISSN: 1878-5506 ISO Abbreviation: Sleep Med. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898759 Medline TA: Sleep Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 837-42 Citation Subset: IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. drboy48@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Blood Pressure* / physiology Body Mass Index Continuous Positive Airway Pressure* Female Humans Logistic Models Male Multivariate Analysis Odds Ratio Regression Analysis Retrospective Studies Sex Factors Sleep / physiology Sleep Apnea, Obstructive / physiopathology, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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