| Does 1,25-dihydroxyvitamin D participate in the regulation of hormone release from endocrine glands? | |
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MedLine Citation:
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PMID: 2981087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of receptors for 1,25-dihydroxyvitamin D3 in the pituitary, pancreas, testis, and ovary has raised the question of a possible direct role for 1,25-dihydroxyvitamin D (1,25(OH)2D) in the regulation of hormone synthesis and secretion. To evaluate this problem, six children with the syndrome of resistance to 1,25(OH)2D with rickets and alopecia underwent dynamic tests of insulin, TSH, PRL, GH, and testosterone secretion. Oral glucose loading resulted in normal glucose curves, subnormal peak insulin responses of 12-20 microU/ml in three hypocalcemic patients, and normal peak serum insulin values of 30-40 microU/ml in two normocalcemic patients. Basal serum, TSH, PRL, T4, and T3 concentrations were normal in all patients. Peak serum TSH values after TRH were 11-17 and 16-32 microU/ml in the hypo- and normocalcemic patients, respectively. The PRL response to TRH stimulation in either hypocalcemic or normocalcemic patients was normal [mean 26.2 +/- 5.1 (SD) ng/ml]. Peak serum GH levels were greater than 8 ng/ml in all five patients studied after one or more of the various stimuli. Serum testosterone concentrations after hCG stimulation were normal in the three patients studied (4.1-8.0 ng/ml). Thus, in children with resistance to 1,25(OH)2D, we could find no significant abnormalities in hormone secretion from the pituitary, pancreas, and testis apart from those presumably due to the hypocalcemia itself. |
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Authors:
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Z Hochberg; Z Borochowitz; A Benderli; P Vardi; S Oren; Z Spirer; I Heyman; Y Weisman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 60 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-01-23 Completed Date: 1985-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 57-61 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcitriol
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physiology* Calcium / blood Child Child, Preschool Chorionic Gonadotropin / diagnostic use Clonidine / diagnostic use Endocrine Glands / secretion* Female Fibroblasts / metabolism Glucose Tolerance Test Growth Hormone / blood Hormones / secretion* Humans Hypophosphatemia, Familial / metabolism* Infant Insulin / blood Levodopa / diagnostic use Male Prolactin / blood Receptors, Calcitriol Receptors, Steroid / metabolism Testosterone / blood Thyrotropin / blood Thyrotropin-Releasing Hormone / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Hormones; 0/Levodopa; 0/Receptors, Calcitriol; 0/Receptors, Steroid; 11061-68-0/Insulin; 24305-27-9/Thyrotropin-Releasing Hormone; 32222-06-3/Calcitriol; 4205-90-7/Clonidine; 58-22-0/Testosterone; 7440-70-2/Calcium; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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