Document Detail


Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model: a preliminary report.
MedLine Citation:
PMID:  25460332     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Dodecafluoropentane emulsion (DDFPe), an oxygen transport agent, has been shown to reduce infarct volume in animal models of acute ischemic stroke (AIS). Our study assesses the effect of DDFPe on MRI markers of infarct evolution in the early hours after vascular occlusion in a rat AIS model. We hypothesized that DDFPe will delay the development of MRI markers of AIS and/or reduce the extent of infarction.
METHODS: Permanent, unilateral surgical occlusion of the middle cerebral and common carotid arteries was performed in control (n=4) and treatment (n=10) rats. The treatment group received 1 IV dose of 2% w/v DDFPe at 0.6mL/kg at 1hour post-occlusion versus none. Diffusion-weighted (DWI) and inversion recovery (IR) MRI sequences were obtained over the 4hours following occlusion. Infarct extent was quantified by number of abnormal MRI slices per sequence for each group and time point. Student's T-test was applied.
RESULTS: DDFPe-treated rats demonstrated reduced infarct extent versus controls over combined time points on IR at 5.43±0.40 (mean±standard error) abnormal slices vs. 7.38±0.58 (P=0.01) and on DWI at 5.21±0.54 vs. 9.00±0.95 (P<0.01). Development of abnormal MRI signal was delayed in the treatment group.
CONCLUSIONS: DDFPe delays and reduces MRI markers of AIS in the early hours following vascular occlusion in a rat stroke model. Further investigation of DDFPe as a neuroprotectant is warranted.
Authors:
R T Fitzgerald; X Ou; J S Nix; M C Arthur; A T Brown; R D Skinner; M J Borrelli; W C Culp
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-8
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  -     ISSN:  1873-5894     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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