Document Detail


Docosanol: new drug. Herpes labialis: barely more effective than an excipient.
MedLine Citation:
PMID:  19637417     Owner:  HSR     Status:  MEDLINE    
Abstract/OtherAbstract:
(1) Herpes is a contagious, recurrent viral infection of the skin and mucous membranes. In immunocompetent patients the recurrences can be troublesome but they heal spontaneously. Management is mainly based on lifestyle measures. Local application of an antiviral drug such as aciclovir has modest effects. It reduces healing time by about 2 days provided treatment is started as soon as the first symptoms appear; (2) Docosanol, a fatty alcohol, was recently authorized in France for treatment of episodes of herpes labialis; (3) A trial in 474 patients showed no tangible difference between docosanol and 5% aciclovir in reducing healing time; (4) Clinical evaluation also includes two trials versus an excipient (polyethylene glycol) including 370 and 373 patients. The median healing time was reduced by less than a day; (5) In these trials, the adverse effects of docosanol were similar to those of the excipients. In particular, docosanol cream contains excipients that can provoke allergic reactions; (6) In practice, docosanol cream is barely or no more effective than an excipient in treating acute episodes of herpes labialis. Lifestyle measures are still the cornerstone of herpes management.
Authors:
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  18     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  106-7     Citation Subset:  T    
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MeSH Terms
Descriptor/Qualifier:
Acyclovir / administration & dosage,  adverse effects,  therapeutic use
Antiviral Agents / administration & dosage,  adverse effects,  therapeutic use
Double-Blind Method
Drug Approval
Excipients / administration & dosage,  adverse effects,  therapeutic use
Fatty Alcohols / administration & dosage,  adverse effects,  therapeutic use*
France
Herpes Labialis / drug therapy*
Humans
Polyethylene Glycols / administration & dosage,  adverse effects,  therapeutic use
Randomized Controlled Trials as Topic
Stearic Acids / administration & dosage,  adverse effects,  therapeutic use
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Excipients; 0/Fatty Alcohols; 0/Polyethylene Glycols; 0/Stearic Acids; 59277-89-3/Acyclovir; 661-19-8/docosanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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