| Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. | |
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MedLine Citation:
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PMID: 15041028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The central nervous system has the second highest concentration of lipids after adipose tissue. Long chain fatty acids, particularly arachidonic acid and docosahexaenoic acid, are integral components of neural membrane phospholipids. Alterations in neural membrane phospholipid components cannot only influence crucial intracellular and intercellular signaling but also alter many membrane physical properties such as fluidity, phase transition temperature, bilayer thickness, and lateral domains. A deficiency of docosahexaenoic acid markedly affects neurotransmission, membrane-bound enzyme and ion channel activities, gene expression, intensity of inflammation, and immunity and synaptic plasticity. Docosahexaenoic acid deficiency is associated with normal aging, Alzheimer disease, hyperactivity, schizophrenia, and peroxisomal disorders. Although the molecular mechanism of docosahexaenoic acid involvement in the disorders remains unknown, the supplementation of docosahexaenoic acid in the diet restores gene expression and modulates neurotransmission. Also, improvements are seen in signal transduction processes associated with behavioral deficits, learning activity, peroxisomal disorders, and psychotic changes in schizophrenia, depression, hyperactivity, stroke, and Alzheimer disease. |
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Authors:
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Lloyd A Horrocks; Akhlaq A Farooqui |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 70 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-25 Completed Date: 2005-11-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 361-72 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA. horrocks.2@osu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / drug effects* Diet Docosahexaenoic Acids / administration & dosage, metabolism, pharmacology*, therapeutic use* Humans Nervous System Diseases / drug therapy*, metabolism Neurons / cytology*, drug effects*, metabolism Phospholipids / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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