Document Detail

Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition.
MedLine Citation:
PMID:  18620024     Owner:  NLM     Status:  MEDLINE    
Omega-3 fatty acids (i.e. docosahexaenoic acid; DHA), similar to exercise, improve cognitive function, promote neuroplasticity, and protect against neurological lesion. In this study, we investigated a possible synergistic action between DHA dietary supplementation and voluntary exercise on modulating synaptic plasticity and cognition. Rats received DHA dietary supplementation (1.25% DHA) with or without voluntary exercise for 12 days. We found that the DHA-enriched diet significantly increased spatial learning ability, and these effects were enhanced by exercise. The DHA-enriched diet increased levels of pro-brain-derived neurotrophic factor (BDNF) and mature BDNF, whereas the additional application of exercise boosted the levels of both. Furthermore, the levels of the activated forms of CREB and synapsin I were incremented by the DHA-enriched diet with greater elevation by the concurrent application of exercise. While the DHA diet reduced hippocampal oxidized protein levels, a combination of a DHA diet and exercise resulted in a greater reduction rate. The levels of activated forms of hippocampal Akt and CaMKII were increased by the DHA-enriched diet, and with even greater elevation by a combination of diet and exercise. Akt and CaMKII signaling are crucial step by which BDNF exerts its action on synaptic plasticity and learning and memory. These results indicate that the DHA diet enhanced the effects of exercise on cognition and BDNF-related synaptic plasticity, a capacity that may be used to promote mental health and reduce risk of neurological disorders.
A Wu; Z Ying; F Gomez-Pinilla
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-06-17
Journal Detail:
Title:  Neuroscience     Volume:  155     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-12-18     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  751-9     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Behavior, Animal / drug effects
Brain-Derived Neurotrophic Factor / metabolism
CREB-Binding Protein / metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism
Cognition / drug effects*,  physiology
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*
Maze Learning / drug effects
Models, Biological
Neuronal Plasticity / drug effects*
Oxidative Stress / drug effects
Physical Conditioning, Animal*
Proto-Oncogene Proteins c-akt / metabolism
Rats, Sprague-Dawley
Reaction Time / drug effects
Time Factors
Grant Support
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 25167-62-8/Docosahexaenoic Acids; EC Protein; EC Proteins c-akt; EC Protein Kinase Type 2

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