| Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. | |
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MedLine Citation:
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PMID: 18620024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 fatty acids (i.e. docosahexaenoic acid; DHA), similar to exercise, improve cognitive function, promote neuroplasticity, and protect against neurological lesion. In this study, we investigated a possible synergistic action between DHA dietary supplementation and voluntary exercise on modulating synaptic plasticity and cognition. Rats received DHA dietary supplementation (1.25% DHA) with or without voluntary exercise for 12 days. We found that the DHA-enriched diet significantly increased spatial learning ability, and these effects were enhanced by exercise. The DHA-enriched diet increased levels of pro-brain-derived neurotrophic factor (BDNF) and mature BDNF, whereas the additional application of exercise boosted the levels of both. Furthermore, the levels of the activated forms of CREB and synapsin I were incremented by the DHA-enriched diet with greater elevation by the concurrent application of exercise. While the DHA diet reduced hippocampal oxidized protein levels, a combination of a DHA diet and exercise resulted in a greater reduction rate. The levels of activated forms of hippocampal Akt and CaMKII were increased by the DHA-enriched diet, and with even greater elevation by a combination of diet and exercise. Akt and CaMKII signaling are crucial step by which BDNF exerts its action on synaptic plasticity and learning and memory. These results indicate that the DHA diet enhanced the effects of exercise on cognition and BDNF-related synaptic plasticity, a capacity that may be used to promote mental health and reduce risk of neurological disorders. |
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Authors:
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A Wu; Z Ying; F Gomez-Pinilla |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-06-17 |
Journal Detail:
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Title: Neuroscience Volume: 155 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2008-12-18 Revised Date: 2011-11-07 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 751-9 Citation Subset: IM |
Affiliation:
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Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Behavior, Animal / drug effects Brain-Derived Neurotrophic Factor / metabolism CREB-Binding Protein / metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Cognition / drug effects*, physiology Dietary Supplements* Docosahexaenoic Acids / administration & dosage* Maze Learning / drug effects Models, Biological Neuronal Plasticity / drug effects* Oxidative Stress / drug effects Physical Conditioning, Animal* Proto-Oncogene Proteins c-akt / metabolism Rats Rats, Sprague-Dawley Reaction Time / drug effects Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NS50465/NS/NINDS NIH HHS; R01 NS050465-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 25167-62-8/Docosahexaenoic Acids; EC 2.3.1.48/CREB-Binding Protein; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinase Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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