Document Detail


Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia.
MedLine Citation:
PMID:  21178607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: With important effects on neuronal lipid composition, neurochemical signaling and cerebrovascular pathobiology, docosahexaenoic acid (DHA), a n-3 polyunsaturated fatty acid, may emerge as a neuroprotective agent against cerebrovascular disease. This paper examines pathways for DHA accretion in brain and evidence for possible roles of DHA in prophylactic and therapeutic approaches for cerebrovascular disease.
RECENT FINDINGS: DHA is a major n-3 fatty acid in the mammalian central nervous system and enhances synaptic activities in neuronal cells. DHA can be obtained through diet or to a limited extent via conversion from its precursor, α-linolenic acid (α-LNA). DHA attenuates brain necrosis after hypoxic ischemic injury, principally by modulating membrane biophysical properties and maintaining integrity in functions between presynaptic and postsynaptic areas, resulting in better stabilizing intracellular ion balance in hypoxic-ischemic insult. Additionally, DHA alleviates brain apoptosis, by inducing antiapoptotic activities such as decreasing responses to reactive oxygen species, upregulating antiapoptotic protein expression, downregulating apoptotic protein expression, and maintaining mitochondrial integrity and function.
SUMMARY: DHA in brain relates to a number of efficient delivery and accretion pathways. In animal models DHA renders neuroprotection after hypoxic-ischemic injury by regulating multiple molecular pathways and gene expression.
Authors:
Korapat Mayurasakorn; Jill J Williams; Vadim S Ten; Richard J Deckelbaum
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  14     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-11     Completed Date:  2011-03-21     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  158-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / drug effects,  metabolism*,  pathology
Docosahexaenoic Acids / administration & dosage,  metabolism*
Fatty Acids, Omega-3 / administration & dosage,  metabolism
Humans
Hypoxia-Ischemia, Brain / metabolism*,  pathology,  prevention & control
Neuroprotective Agents / administration & dosage,  metabolism*
Reperfusion Injury / prevention & control*
Grant Support
ID/Acronym/Agency:
HL 40404/HL/NHLBI NIH HHS; M01 RR000645/RR/NCRR NIH HHS; NS 056146/NS/NINDS NIH HHS; P50 HL056984/HL/NHLBI NIH HHS; R01 HL040404/HL/NHLBI NIH HHS; T32 DK007647/DK/NIDDK NIH HHS; T32 DK007715/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Neuroprotective Agents; 25167-62-8/Docosahexaenoic Acids

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