Document Detail


Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.
MedLine Citation:
PMID:  21756134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be obtained from the diet to sustain homeostasis. Omega-3 and -6 PUFAs are key components of biomembranes and play important roles in cell integrity, development, maintenance, and function. The essential omega-3 fatty acid family member docosahexaenoic acid (DHA) is avidly retained and uniquely concentrated in the nervous system, particularly in photoreceptors and synaptic membranes. DHA plays a key role in vision, neuroprotection, successful aging, memory, and other functions. In addition, DHA displays anti-inflammatory and inflammatory resolving properties in contrast to the proinflammatory actions of several members of the omega-6 PUFAs family. This review discusses DHA signalolipidomics, comprising the cellular/tissue organization of DHA uptake, its distribution among cellular compartments, the organization and function of membrane domains rich in DHA-containing phospholipids, and the cellular and molecular events revealed by the uncovering of signaling pathways regulated by DHA and docosanoids, the DHA-derived bioactive lipids, which include neuroprotectin D1 (NPD1), a novel DHA-derived stereoselective mediator. NPD1 synthesis agonists include neurotrophins and oxidative stress; NPD1 elicits potent anti-inflammatory actions and prohomeostatic bioactivity, is anti-angiogenic, promotes corneal nerve regeneration, and induces cell survival. In the context of DHA signalolipidomics, this review highlights aging and the evolving studies on the significance of DHA in Alzheimer's disease, macular degeneration, Parkinson's disease, and other brain disorders. DHA signalolipidomics in the nervous system offers emerging targets for pharmaceutical intervention and clinical translation.
Authors:
Nicolas G Bazan; Miguel F Molina; William C Gordon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annual review of nutrition     Volume:  31     ISSN:  1545-4312     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-15     Completed Date:  2011-11-18     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-51     Citation Subset:  IM    
Affiliation:
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. nbazan@lsuhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Deficiency Diseases / physiopathology
Diet / adverse effects
Docosahexaenoic Acids / analogs & derivatives,  metabolism*
Fatty Acids, Essential / deficiency,  metabolism
Gene Expression Regulation
Humans
Macular Degeneration / etiology,  metabolism
Metabolomics / methods*
Neuritis / etiology,  metabolism
Neurodegenerative Diseases / etiology,  metabolism
Signal Transduction*
Grant Support
ID/Acronym/Agency:
AT005909/AT/NCCAM NIH HHS; EY005121/EY/NEI NIH HHS; NS046741/NS/NINDS NIH HHS; R01 EY005121/EY/NEI NIH HHS; RR016816/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 25167-62-8/Docosahexaenoic Acids
Comments/Corrections

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