| Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. | |
| | |
MedLine Citation:
|
PMID: 21756134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be obtained from the diet to sustain homeostasis. Omega-3 and -6 PUFAs are key components of biomembranes and play important roles in cell integrity, development, maintenance, and function. The essential omega-3 fatty acid family member docosahexaenoic acid (DHA) is avidly retained and uniquely concentrated in the nervous system, particularly in photoreceptors and synaptic membranes. DHA plays a key role in vision, neuroprotection, successful aging, memory, and other functions. In addition, DHA displays anti-inflammatory and inflammatory resolving properties in contrast to the proinflammatory actions of several members of the omega-6 PUFAs family. This review discusses DHA signalolipidomics, comprising the cellular/tissue organization of DHA uptake, its distribution among cellular compartments, the organization and function of membrane domains rich in DHA-containing phospholipids, and the cellular and molecular events revealed by the uncovering of signaling pathways regulated by DHA and docosanoids, the DHA-derived bioactive lipids, which include neuroprotectin D1 (NPD1), a novel DHA-derived stereoselective mediator. NPD1 synthesis agonists include neurotrophins and oxidative stress; NPD1 elicits potent anti-inflammatory actions and prohomeostatic bioactivity, is anti-angiogenic, promotes corneal nerve regeneration, and induces cell survival. In the context of DHA signalolipidomics, this review highlights aging and the evolving studies on the significance of DHA in Alzheimer's disease, macular degeneration, Parkinson's disease, and other brain disorders. DHA signalolipidomics in the nervous system offers emerging targets for pharmaceutical intervention and clinical translation. |
| | |
Authors:
|
Nicolas G Bazan; Miguel F Molina; William C Gordon |
Related Documents
:
|
20154194 - Tracking the oxidative kinetics of carbohydrates, amino acids and fatty acids in the ho... 8383004 - Lipid hydroperoxides greatly increase the rate of oxidative catabolism of all-trans-ret... 2513284 - Liberation of 14co2 from 14c-fatty acids by riboflavin-deficient sucking rat pups: a st... 12470654 - Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator. 6342444 - Effects of nutrition and alcohol on albumin synthesis. 22063794 - Carcass composition and meat quality of three different iberian×duroc genotype pigs. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annual review of nutrition Volume: 31 ISSN: 1545-4312 ISO Abbreviation: Annu. Rev. Nutr. Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-15 Completed Date: 2011-11-18 Revised Date: 2013-05-24 |
Medline Journal Info:
|
Nlm Unique ID: 8209988 Medline TA: Annu Rev Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 321-51 Citation Subset: IM |
Affiliation:
|
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. nbazan@lsuhsc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
metabolism Animals Deficiency Diseases / physiopathology Diet / adverse effects Docosahexaenoic Acids / analogs & derivatives, metabolism* Fatty Acids, Essential / deficiency, metabolism Gene Expression Regulation Humans Macular Degeneration / etiology, metabolism Metabolomics / methods* Neuritis / etiology, metabolism Neurodegenerative Diseases / etiology, metabolism Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
|
AT005909/AT/NCCAM NIH HHS; EY005121/EY/NEI NIH HHS; NS046741/NS/NINDS NIH HHS; R01 EY005121/EY/NEI NIH HHS; RR016816/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Essential; 25167-62-8/Docosahexaenoic Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: How many people are malnourished?
Next Document: Effects of Forearm vs. Leg Submersion in Work Tolerance Time in a Hot Environment While Wearing Fire...