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Docosahexaenoic Acid, but not Eicosapentaenoic Acid, Reduces the Early Inflammatory Response Following Compression Spinal Cord Injury in the Rat.
MedLine Citation:
PMID:  22404382     Owner:  NLM     Status:  Publisher    
Docosahexaenoic acid (DHA, 22:6) and eicosapentaenoic acid (EPA, 20:5) are omega-3 polyunsaturated fatty acids (n-3 PUFAs) with distinct anti-inflammatory properties. Both have neuroprotective effects acutely following spinal cord injury (SCI). We examined the effect of intravenous DHA and EPA on early inflammatory events after SCI. Saline, DHA or EPA (both 250 nmol/kg) were administered 30 minutes after T12 compression SCI, to female Sprague-Dawley rats. DHA significantly reduced the number of neutrophils to some areas of the injured epicentre at 4 h and 24 h. DHA also reduced C-Reactive Protein (CRP) plasma levels, whereas EPA did not significantly reduce neutrophils or CRP. Laminectomy and SCI elicited a sustained inflammatory response in the liver, which was not reversed by the PUFAs. The chemokine KC/GRO/CINC and the cytokine IL-6 provide gradients for chemotaxis of neutrophils to the epicentre. At 4 h after injury, there was a significant increase in IL-6, KC/GRO/CINC, IL-1β and TNF-α in the epicentre, with a return to baseline at 24 h. Neither DHA nor EPA returned their levels to control values. These results indicate that the acute neuroprotective effects of n-3 PUFAs in rat compression SCI may be only partly attributed to reduction of some of the early inflammatory events occurring after injury. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
Jodie Ce Hall; John V Priestley; V Hugh Perry; Adina T Michael-Titus
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-8
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio, 43210, USA. Centre for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK. Southampton Neuroscience Group, School of Biological Sciences & School of Medicine, University of Southampton, Southampton, UK.
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