Document Detail


Docosahexaenoic acid-containing phospholipids and triglycerides based nutritional supplements.
MedLine Citation:
PMID:  20863272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dietary deficiency of docosahexaenoic acid (DHA) is associated with a variety of human diseases, such as brain disorders and infertility. Because of the capacity to convert DHA precursors, such as α-linolenic acid, to DHA is very limited in the human tissues and the brain, it has to be supplied in the diet. A great number of both in vivo and in vitro investigations have shown pharmacological and nutritional effects of DHA and its metabolites in animal tests and experiments at cell level, but limited documents discussed on how and why DHA can or cannot reach the target tissues to alleviate disorders after oral administration. A pure DHA intake in the form of a free fatty acid causes gastrointestinal complains. On the other hand, free DHA is unstable to oxidation and also difficult to be incorporated into delivering vehicles. Generally, DHA can be transported into tissues and the brain via plasma vehicle, and the major DHA carriers used in dietary supplements are phospholipids (PLs) and triglycerides (TGs). In the present paper, the key points center around proposed mechanisms mainly on (i) how the DHA carriers can be absorbed and distributed in the delivery of DHA into human tissues and the brain, and (ii) how consumers can benefit from nutritional supplements that contain the DHA carriers, particularly in the improvement of cognitive decline and fertility. It is also expected that this review may significantly help with driving sellers and consumers into a new way to choose various DHA supplements for human health. The article presents some promising patents on docosahexaenoic acid-containing phospholipids and triglycerides based nutritional supplements.
Authors:
Su Chen; Rainbow Chen
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Recent patents on food, nutrition & agriculture     Volume:  2     ISSN:  1876-1429     ISO Abbreviation:  Recent Pat Food Nutr Agric     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-12     Completed Date:  2011-03-04     Revised Date:  2012-10-16    
Medline Journal Info:
Nlm Unique ID:  101526178     Medline TA:  Recent Pat Food Nutr Agric     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  213-20     Citation Subset:  IM    
Affiliation:
Research and Development, Chainon Neurotrophin Biotechnology Inc., 41 Bayberry Dr., Malta, NY 12020, USA. su@chainonbio.com
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MeSH Terms
Descriptor/Qualifier:
Cognition Disorders / drug therapy
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*,  deficiency,  metabolism
Drug Carriers
Humans
Infertility / drug therapy
Patents as Topic*
Phospholipids / chemistry
Triglycerides / chemistry
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Phospholipids; 0/Triglycerides; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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