Document Detail

Docosahexaenoic Acid, But Not Eicosapentaenoic Acid, Supplementation Reduces Vulnerability to Atrial Fibrillation.
MedLine Citation:
PMID:  22923273     Owner:  NLM     Status:  Publisher    
BACKGROUND: -The potential health benefits of omega-3 polyunsaturated fatty acids (PUFAs) are usually studied using a combination of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).This combination reduces vulnerability to experimentally induced atrial fibrillation (AF). It is unknown whether EPA and DHA have differential effects when taken alone. Using a model of pacing induced atrial hemodynamic overload we investigated the individual effects of EPA and DHA on vulnerability to AF and atrial remodeling. METHODS AND RESULTS: -Thirty-four dogs were randomized into 3 groups all of which underwent simultaneous atrial and ventricular pacing (SAVP) at 220bpm for 14 days. One group received purified DHA (~1g/day) orally for 21 days beginning 7 days before pacing began. Similarly, one group received ~1g/day purified EPA. In a third (control) group, (No-PUFAs), 8dogs received ~1g/day olive oil, 12 were unsupplemented. Electrophysiologic and echocardiographic measurements were taken at baseline and 21 days. Atrial tissue samples were collected at 21 days for histologic and molecular analyses. Persistent AF inducibility was significantly reduced by DHA compared to No-PUFAs (0% [0-3%] median [25-75 percentiles] for DHA vs. 3.1% [2.2-11%] for No-PUFAs, P=0.007), but not by EPA (3.4% [1.9-8.9%]). DHA also reduced atrial fibrosis compared to No-PUFAs (11±6% vs. 20±4% respectively, P<0.05),whereas EPA did not (15±5%, P>0.05). CONCLUSIONS: -DHA is more effective than EPA in attenuating AF vulnerability and atrial remodeling instructural remodeling induced AF.
Andrew Ramadeen; Kim A Connelly; Howard Leong-Poi; Xudong Hu; Hiroko Fujii; Gabriel Laurent; Anthony F Domenichiello; Richard P Bazinet; Paul Dorian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-24
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 St. Michael's Hospital & University of Toronto, Toronto, ON, Canada;
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