Document Detail


Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis.
MedLine Citation:
PMID:  22038210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Essential fatty acids are important for growth, development, and physiologic function. α-Linolenic acid and linoleic acid are the precursors of docosahexaenoic and arachidonic acid, respectively, and have traditionally been considered the essential fatty acids. However, the authors hypothesized that docosahexaenoic acid and arachidonic acid can function as the essential fatty acids.
METHODS: Using a murine model of essential fatty acid deficiency and consequent hepatic steatosis, the authors provided mice with varying amounts of docosahexaenoic and arachidonic acids to determine whether exclusive supplementation of docosahexaenoic and arachidonic acids could prevent essential fatty acid deficiency and inhibit or attenuate hepatic steatosis.
RESULTS: Mice supplemented with docosahexaenoic and arachidonic acids at 2.1% or 4.2% of their calories for 19 days had normal liver histology and no biochemical evidence of essential fatty acid deficiency, which persisted when observed after 9 weeks.
CONCLUSION: Supplementation of sufficient amounts of docosahexaenoic and arachidonic acids alone without α-linolenic and linoleic acids meets essential fatty acid requirements and prevents hepatic steatosis in a murine model.
Authors:
Hau D Le; Jonathan A Meisel; Vincent E de Meijer; Erica M Fallon; Kathleen M Gura; Vania Nose; Bruce R Bistrian; Mark Puder
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-30
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  36     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-20     Completed Date:  2012-11-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-41     Citation Subset:  IM    
Affiliation:
Department of Surgery and the Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / administration & dosage*
Dietary Supplements*
Disease Models, Animal
Docosahexaenoic Acids / administration & dosage*
Energy Intake
Fatty Acids, Essential / deficiency*
Fatty Liver / prevention & control*
Mice
Mice, Inbred C57BL
Plant Oils / administration & dosage
Grant Support
ID/Acronym/Agency:
DK069621-05/DK/NIDDK NIH HHS; F32 DK083880/DK/NIDDK NIH HHS; F32DK083880/DK/NIDDK NIH HHS; K08 DK069621/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Plant Oils; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 8001-31-8/coconut oil
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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