| Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. | |
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MedLine Citation:
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PMID: 22038210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Essential fatty acids are important for growth, development, and physiologic function. α-Linolenic acid and linoleic acid are the precursors of docosahexaenoic and arachidonic acid, respectively, and have traditionally been considered the essential fatty acids. However, the authors hypothesized that docosahexaenoic acid and arachidonic acid can function as the essential fatty acids. METHODS: Using a murine model of essential fatty acid deficiency and consequent hepatic steatosis, the authors provided mice with varying amounts of docosahexaenoic and arachidonic acids to determine whether exclusive supplementation of docosahexaenoic and arachidonic acids could prevent essential fatty acid deficiency and inhibit or attenuate hepatic steatosis. RESULTS: Mice supplemented with docosahexaenoic and arachidonic acids at 2.1% or 4.2% of their calories for 19 days had normal liver histology and no biochemical evidence of essential fatty acid deficiency, which persisted when observed after 9 weeks. CONCLUSION: Supplementation of sufficient amounts of docosahexaenoic and arachidonic acids alone without α-linolenic and linoleic acids meets essential fatty acid requirements and prevents hepatic steatosis in a murine model. |
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Authors:
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Hau D Le; Jonathan A Meisel; Vincent E de Meijer; Erica M Fallon; Kathleen M Gura; Vania Nose; Bruce R Bistrian; Mark Puder |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-10-30 |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 36 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-20 Completed Date: 2012-11-05 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 431-41 Citation Subset: IM |
Affiliation:
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Department of Surgery and the Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / administration & dosage* Dietary Supplements* Disease Models, Animal Docosahexaenoic Acids / administration & dosage* Energy Intake Fatty Acids, Essential / deficiency* Fatty Liver / prevention & control* Mice Mice, Inbred C57BL Plant Oils / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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DK069621-05/DK/NIDDK NIH HHS; F32DK083880/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 0/Plant Oils; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 8001-31-8/coconut oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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