| Docking study of the precursor peptide of mastoparan onto its putative processing enzyme, dipeptidyl peptidase IV: a revisit to molecular ticketing. | |
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MedLine Citation:
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PMID: 20306218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stepwise-cleavage process of promastoparans to reach maturity was investigated theoretically by combining ab initio folding and unbounded docking. The comparison between the structures of the promastoparans both before and after docking were examined along with the hydrogen bonding interaction pattern between the dipetidyl peptidase IV (DPPIV) and promastoparans to reveal how the endpoint of this stepwise cleavage is recognized among these promastoparans with highly resemble amino acid sequences. The current approach of folding and docking study provides structural insight on the stepwise cleavage process. |
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Authors:
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Soonmin Jang; Tse-Yu Chung; Jungho Shin; Kai-Lun Lin; Jason T C Tzen; Feng-Yin Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-20 |
Journal Detail:
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Title: Journal of computer-aided molecular design Volume: 24 ISSN: 1573-4951 ISO Abbreviation: J. Comput. Aided Mol. Des. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710425 Medline TA: J Comput Aided Mol Des Country: Netherlands |
Other Details:
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Languages: eng Pagination: 213-24 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Institute for Chemical Biology, Sejong University, Seoul, 143-747, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Antigens, CD26 / metabolism* Hydrogen Bonding Molecular Dynamics Simulation* Molecular Sequence Data Peptides / chemistry, metabolism* Protein Binding Protein Folding Surface-Active Agents / metabolism* Wasp Venoms / chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Surface-Active Agents; 0/Wasp Venoms; 72093-21-1/mastoparan; EC 3.4.14.5/Antigens, CD26 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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