| Docetaxel plus prednisone in patients with metastatic hormone-refractory prostate cancer: an Italian clinical experience. | |
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MedLine Citation:
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PMID: 21528780 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS AND BACKGROUND: We investigated the efficacy of docetaxel plus prednisone in Italian patients with metastatic hormone-refractory prostate cancer (mHRPC). METHODS: Twenty four patients with mHRPC received docetaxel 75 mg/m2 every 3 weeks plus prednisone 5 mg twice daily for up to six cycles. The primary endpoint was efficacy measured by a reduction in serum prostate specific antigen (PSA) levels and measurable disease. Evaluation of toxicity, quality of life and reduction of pain were secondary endpoints. RESULTS: PSA response was seen in 18 patients (75%). We observed a partial response in 2 patients (8.3%), stable disease in 10 patients (41.7%), and disease progression in 12 patients (50%). Severe neutropenia was reported in 12.5% of patients. CONCLUSIONS: Treatment with docetaxel every three weeks is an effective and well tolerated therapeutic option in patients with mHRPC. |
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Authors:
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G Cicero; R De Luca |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European review for medical and pharmacological sciences Volume: 15 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Affiliation:
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Oncology Department, Medical Oncology Unit, Policlinico Universitario, University of Palermo, Italy. giuseppecicero@unipa.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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