Document Detail


Docetaxel does not impair cardiac autonomic function in breast cancer patients previously treated with anthracyclines.
MedLine Citation:
PMID:  11984089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of docetaxel treatment on autonomic cardiac function was studied with 24-h ECG recordings in breast cancer patients pretreated with anthracyclines. Twenty-four women were evaluated before docetaxel treatment and after 3-4 courses of docetaxel 100 mg/m(2). The heart rate, cardiac extrasystoles and heart rate variability (HRV) in both the time and frequency domain were assessed from 24-h ECG recordings. The acute effects of docetaxel were calculated from 1-h recordings immediately prior to, during and after infusion. Long-term effects were evaluated from 24-h recordings performed before treatment and after 3-4 courses of docetaxel. There was no increase in the number of cardiac extrasystoles during docetaxel infusion. The number of ventricular extrasystoles decreased from 14 (23) to 7 (14) during and 5 (10) after the first infusion (p=0.02). The heart rate, HRV and extrasystoles were similar before and after 3-4 courses of docetaxel. The treatment did not abolish circadian variability of the heart rate. Docetaxel did not deteriorate autonomic cardiac function. In conclusion, our findings suggest that docetaxel does not have harmful cumulative effects on autonomic control of the heart and is therefore unlikely to be cardiotoxic.
Authors:
Eeva Ekholm; Virpi Rantanen; Kari Syvänen; Jarmo Jalonen; Kari Antila; Eeva Salminen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Anti-cancer drugs     Volume:  13     ISSN:  0959-4973     ISO Abbreviation:  Anticancer Drugs     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-01     Completed Date:  2002-12-17     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9100823     Medline TA:  Anticancer Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Turku, 20520 Turku, Finland. eeva.ekholm@fimnet.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibiotics, Antineoplastic / therapeutic use*
Antineoplastic Agents, Phytogenic / adverse effects*,  therapeutic use*
Breast Neoplasms / drug therapy*,  physiopathology
Circadian Rhythm / drug effects
Electrocardiography / drug effects
Female
Heart Rate / drug effects
Humans
Middle Aged
Paclitaxel / adverse effects*,  analogs & derivatives*,  therapeutic use*
Taxoids*
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents, Phytogenic; 0/Taxoids; 15H5577CQD/docetaxel; 33069-62-4/Paclitaxel

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