Document Detail

Dobutamine stress radionuclide ventriculography reveals silent myocardial dysfunction in Kawasaki disease.
MedLine Citation:
PMID:  11999668     Owner:  NLM     Status:  MEDLINE    
Dobutamine (DOB) stress radionuclide ventriculography (RVG) is proposed for evaluating left ventricular performance in patients with Kawasaki disease (KD). Dobutamine stress RVG, up to 15 microg x kg(-1) x min(-1), was performed in 40 patients with a history of KD, some of whom had a perfusion defect (PD group) on dipyridamole stress thallium-201 myocardial imaging, some of whom had no perfusion defects (NPD group), and some of whom had no coronary artery lesions (C group). No significant differences in either systolic or diastolic indices of the left ventricle at rest were observed between the 3 groups. Although hemodynamic responses were similar in all patients after DOB stress, early diastolic index of the first third filling fraction decreased only in the PD group and was significantly lower in this group compared with the C group (p<0.01). The asynchrony index increased significantly in those patients with coronary stenosis after DOB stress (p<0.05). No serious side-effects were observed during the study. Even late after onset, patients with myocardial ischemia as a result of KD still had impaired early diastolic filling and asynchronous relaxation of the left ventricle. As an alternative to exercise testing, DOB stress RVG is a safe and promising means for serially evaluating left ventricular performance in patients with KD.
Yuji Hamamichi; Fukiko Ichida; Shinichi Tsubata; Keiichi Hirono; Sayaka Watanabe; Chen Rui; Xianyi Yu; Kei-Ichiro Uese; Ikuo Hashimoto; Masashi Simizu; Hikaru Seto; Hideki Origasa; Toshio Miyawaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  66     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-05-09     Completed Date:  2002-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Department of Pediatrics, Toyama Medical & Pharmaceutical University, Japan.
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MeSH Terms
Adrenergic beta-Agonists / diagnostic use*
Blood Pressure / drug effects
Cardiomyopathies / etiology,  radiography,  radionuclide imaging*
Child, Preschool
Coronary Angiography
Dipyridamole / diagnostic use
Dobutamine / diagnostic use*
Exercise Test / methods
Heart / radionuclide imaging
Heart Rate / drug effects
Mucocutaneous Lymph Node Syndrome / physiopathology,  radionuclide imaging*
Radionuclide Ventriculography / drug effects*
Thallium Radioisotopes / diagnostic use
Ventricular Function, Left / physiology,  radiation effects
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Thallium Radioisotopes; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole

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