Document Detail

Dobutamine stress echocardiography: sensitivity, specificity, and predictive value for future cardiac events.
MedLine Citation:
PMID:  8197976     Owner:  NLM     Status:  MEDLINE    
We conducted a retrospective study to determine whether dobutamine stress echocardiography (DE) can be used for risk stratification of patients with known or suspected coronary artery disease (CAD). The study population consisted of 77 patients who underwent DE at our institution. The protocol consisted of an echocardiogram at baseline followed by imaging during intravenous dobutamine infusion starting at 10 micrograms/kg/min with increments of 10 micrograms/kg/min every 3 minutes to a maximum dose of 40 micrograms/kg/min. The reasons for performing DE included preoperative cardiac evaluation (30), chest pain (23), assessment of ischemia (18), and suspected restenosis (6). DE was classified according to wall motion response as normal (before and during DE), fixed abnormal (abnormal before with no change during DE), or ischemic (new wall-motion abnormality during DE). Mean duration of follow-up was 10 months. Cardiac events occurred in 14 patients. These included congestive heart failure in seven patients, myocardial infarction in six, and cardiac death in one. A normal wall-motion response (n = 40) was associated with a low incidence of cardiac events (5%), whereas 5 of 10 patients (50%) with an ischemic response had events. The risk of cardiac events was intermediate (26%) in patients with fixed abnormal wall motion. Overall sensitivity of DE for predicting future cardiac events was 85%. In 45 patients who underwent coronary angiography within 2 months of DE, the test detected CAD with a sensitivity of 71%. In conclusion, the wall-motion response during DE may be used for identifying patients at high risk for future cardiac events.
I Afridi; M A Quiñones; W A Zoghbi; J Cheirif
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  127     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-06-29     Completed Date:  1994-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1510-5     Citation Subset:  AIM; IM    
Department of Internal Medicine, Baylor College of Medicine, Veterans Administration Hospital, Houston, Texas.
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MeSH Terms
Confidence Intervals
Coronary Angiography
Coronary Disease / epidemiology,  radiography,  ultrasonography
Dobutamine* / adverse effects,  diagnostic use*
Echocardiography / instrumentation,  methods*,  statistics & numerical data
Evaluation Studies as Topic
Exercise Test* / statistics & numerical data
Follow-Up Studies
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Retrospective Studies
Sensitivity and Specificity
Texas / epidemiology
Grant Support
Reg. No./Substance:

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