Document Detail

Dobutamine-induced transmural myocardial ischemia in a patient with mild coronary lesions.
MedLine Citation:
PMID:  8821426     Owner:  NLM     Status:  MEDLINE    
A 70-year-old man was admitted for evaluation of retrosternal pain at rest. During infusion of dobutamine (25 micrograms/kg/min) the patient developed angina, ST-segment elevation in the inferior leads, and echocardiographic hypokinesia in the inferior-basal myocardial wall. Coronary angiography revealed insignificant (20-30%) stenosis of the right coronary artery and a normal remaining tree. This case suggests that dobutamine may induce transmural myocardial ischemia in patients with mild coronary lesions, probably by producing occlusive coronary spasm on a substrate of arterial endothelial dysfunction.
F G Kardaras; M S Bonou; D F Kardara; A I Kranidis; E P Sioras; L P Anthopoulos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  19     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-11-21     Completed Date:  1996-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-51     Citation Subset:  IM    
First Department of Cardiology, Evangelismos Hospital, Athens, Greece.
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MeSH Terms
Adrenergic beta-Agonists / adverse effects*
Coronary Angiography
Coronary Disease / diagnosis*,  radiography
Dobutamine / adverse effects*
Myocardial Ischemia / chemically induced*,  diagnosis
Reg. No./Substance:
0/Adrenergic beta-Agonists; 34368-04-2/Dobutamine

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