| Dobutamine-induced improvement in inferior myocardial contractile function predicts reduction in functional mitral regurgitation: a study using tissue Doppler strain rate imaging. | |
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MedLine Citation:
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PMID: 20826593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: left ventricular (LV) remodeling can increase tethering force to mitral valve and functional mitral regurgitation (FMR). Because the relationship between FMR and regional myocardial function has not been quantitatively evaluated, we conducted a quantitative investigation of this association. METHODS AND RESULTS: the effective regurgitant orifice (ERO) of FMR in 51 patients with depressed LV ejection fraction (32±9%) secondary to ischemic or nonischemic cardiomyopathy was compared with mitral deformation (valve and annulus), global LV remodeling (volume indices, function, and sphericity), and regional myocardial contractile function, as assessed by longitudinal peak systolic strain rate (Ssr) in LV anterior, anteroseptal, inferoseptal, inferior, inferolateral, and anterolateral segments at rest. Low-dose dobutamine (10 μg/kg per minute)-induced changes in ERO were compared with changes in the variables. Multivariable analysis identified the predictors of ERO at rest as mitral valvular tenting (β=0.062; P<0.001), Ssr in the inferior segment (inferior Ssr) (β=-0.178; P<0.001), and LV sphericity (β=0.414; P=0.001) and the predictors of valvular tenting at rest as inferior Ssr (β=-1.680; P<0.001), LV end-systolic volume index (β=0.022; P=0.001), and LV sphericity (β=3.886; P=0.012). Furthermore, dobutamine-induced reduction in ERO was predicted by reduction in valvular tenting (β=0.087; P<0.001) and increase in inferior Ssr (β=-0.082; P<0.001), and dobutamine-induced reduction in valvular tenting was predicted by increase in inferior Ssr (β=-0.860; P<0.001). CONCLUSIONS: inferior regional myocardial dysfunction was quantitatively associated with mitral valvular tenting and FMR. Moreover, improvement with dobutamine of inferior myocardial contractile function attenuated valvular tenting and FMR. Inferior myocardial contractile function can affect the configuration of the mitral apparatus and predict FMR severity. |
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Authors:
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Kazuhiro Tatsumi; Hiroya Kawai; Daisuke Sugiyama; Kazuko Norisada; Toshiya Kataoka; Tetsuari Onishi; Hidekazu Tanaka; Ken-Ichi Hirata |
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Publication Detail:
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Type: Journal Article Date: 2010-09-08 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: 3 ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-23 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 638-46 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiotonic Agents / diagnostic use Dobutamine / diagnostic use* Echocardiography, Stress / methods* Female Humans Male Mitral Valve Insufficiency / ultrasonography* Myocardial Contraction / drug effects* Observer Variation Predictive Value of Tests Reproducibility of Results Ultrasonography, Doppler / methods* Ventricular Dysfunction, Left / ultrasonography* Ventricular Remodeling / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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