| Dobutamine: a hemodynamic evaluation in children with shock. | |
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MedLine Citation:
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PMID: 7086606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hemodynamic effects of dobutamine were studied in 33 infants and children with cardiogenic or septic shock. Dobutamine was administered at doses of 2.5, 5.0, 7.5, and 10.0 micrograms/kg/minute. Significant increases above preinfusion values were observed in cardiac index, left ventricular stroke work index, and pulmonary wedge pressure. Significant decreases from preinfusion values were observed in systemic arteriolar resistance index. No significant differences occurred in heart rate, mean systemic arterial pressure, mean pulmonary arterial pressure, right atrial pressure, or pulmonary arteriolar resistance index. Analysis of the data also revealed significant effects of age and diagnosis on the hemodynamic responses. These data suggest that dobutamine is a useful drug in the pharmacologic management of children in shock, especially in children older than 12 months with cardiogenic shock not complicated by severe hypotension. |
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Authors:
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R M Perkin; D L Levin; R Webb; A Aquino; J Reedy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 100 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-08-26 Completed Date: 1982-08-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 977-83 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Body Surface Area Cardiac Output / drug effects Catecholamines / therapeutic use* Child Child, Preschool Dobutamine / adverse effects, therapeutic use* Female Hemodynamics / drug effects* Humans Infant Male Prospective Studies Pulmonary Wedge Pressure / drug effects Shock / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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