Document Detail

Dobutamine: a hemodynamic evaluation in children with shock.
MedLine Citation:
PMID:  7086606     Owner:  NLM     Status:  MEDLINE    
The hemodynamic effects of dobutamine were studied in 33 infants and children with cardiogenic or septic shock. Dobutamine was administered at doses of 2.5, 5.0, 7.5, and 10.0 micrograms/kg/minute. Significant increases above preinfusion values were observed in cardiac index, left ventricular stroke work index, and pulmonary wedge pressure. Significant decreases from preinfusion values were observed in systemic arteriolar resistance index. No significant differences occurred in heart rate, mean systemic arterial pressure, mean pulmonary arterial pressure, right atrial pressure, or pulmonary arteriolar resistance index. Analysis of the data also revealed significant effects of age and diagnosis on the hemodynamic responses. These data suggest that dobutamine is a useful drug in the pharmacologic management of children in shock, especially in children older than 12 months with cardiogenic shock not complicated by severe hypotension.
R M Perkin; D L Levin; R Webb; A Aquino; J Reedy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  100     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  977-83     Citation Subset:  AIM; IM    
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MeSH Terms
Body Surface Area
Cardiac Output / drug effects
Catecholamines / therapeutic use*
Child, Preschool
Dobutamine / adverse effects,  therapeutic use*
Hemodynamics / drug effects*
Prospective Studies
Pulmonary Wedge Pressure / drug effects
Shock / drug therapy*,  physiopathology
Reg. No./Substance:
0/Catecholamines; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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