Document Detail

Dobutamine cardiovascular magnetic resonance for the detection of myocardial ischemia with the use of myocardial tagging.
MedLine Citation:
PMID:  12668491     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to assess the value of high-dose dobutamine cardiovascular magnetic resonance (CMR) with myocardial tagging for the detection of wall motion abnormalities as a measure of myocardial ischemia in patients with known or suspected coronary artery disease. METHODS AND RESULTS: Two hundred eleven consecutive patients with chest pain underwent dobutamine-CMR 4 days after antianginal medication was stopped. Dobutamine-CMR was performed at rest and during increasing doses of dobutamine. Cine-images were acquired during breath-hold with and without myocardial tagging at 3 short-axis levels. Regional wall motion was assessed in a 16-segment short-axis model. Patients with new wall motion abnormalities (NWMA) were examined by coronary angiography. Dobutamine-CMR was successfully performed in 194 patients. Dobutamine-CMR without tagging detected NWMA in 58 patients, whereas NWMA were detected in 68 patients with tagging (P=0.002, McNemar). Coronary angiography showed coronary artery disease in 65 (96%) of these 68 patients. All but 3 of the 65 patients needed revascularization. In the 112 patients with a negative dobutamine-CMR study, without baseline wall motion abnormalities, the cardiovascular occurrence-free survival rate was 98.2% during the mean follow-up period of 17.3 months (range, 7 to 31). CONCLUSIONS: Dobutamine-CMR with myocardial tagging detected more NWMA compared with dobutamine-CMR without tagging and reliably separated patients with a normal life expectancy from those at increased risk of major adverse cardiac events.
Dirkjan Kuijpers; Kai Yiu J A M Ho; Paul R M van Dijkman; Rozemarijn Vliegenthart; Matthijs Oudkerk
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2003-03-17
Journal Detail:
Title:  Circulation     Volume:  107     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1592-7     Citation Subset:  AIM; IM    
Department of Radiology, University Hospital Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
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MeSH Terms
Coronary Angiography
Disease-Free Survival
Dobutamine / diagnostic use*
Heart / physiology
Magnetic Resonance Imaging / methods*
Middle Aged
Myocardial Ischemia / diagnosis*,  mortality,  radiography
Survival Rate
Reg. No./Substance:

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