| Dobutamine cardiovascular magnetic resonance for the detection of myocardial ischemia with the use of myocardial tagging. | |
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MedLine Citation:
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PMID: 12668491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of this study was to assess the value of high-dose dobutamine cardiovascular magnetic resonance (CMR) with myocardial tagging for the detection of wall motion abnormalities as a measure of myocardial ischemia in patients with known or suspected coronary artery disease. METHODS AND RESULTS: Two hundred eleven consecutive patients with chest pain underwent dobutamine-CMR 4 days after antianginal medication was stopped. Dobutamine-CMR was performed at rest and during increasing doses of dobutamine. Cine-images were acquired during breath-hold with and without myocardial tagging at 3 short-axis levels. Regional wall motion was assessed in a 16-segment short-axis model. Patients with new wall motion abnormalities (NWMA) were examined by coronary angiography. Dobutamine-CMR was successfully performed in 194 patients. Dobutamine-CMR without tagging detected NWMA in 58 patients, whereas NWMA were detected in 68 patients with tagging (P=0.002, McNemar). Coronary angiography showed coronary artery disease in 65 (96%) of these 68 patients. All but 3 of the 65 patients needed revascularization. In the 112 patients with a negative dobutamine-CMR study, without baseline wall motion abnormalities, the cardiovascular occurrence-free survival rate was 98.2% during the mean follow-up period of 17.3 months (range, 7 to 31). CONCLUSIONS: Dobutamine-CMR with myocardial tagging detected more NWMA compared with dobutamine-CMR without tagging and reliably separated patients with a normal life expectancy from those at increased risk of major adverse cardiac events. |
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Authors:
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Dirkjan Kuijpers; Kai Yiu J A M Ho; Paul R M van Dijkman; Rozemarijn Vliegenthart; Matthijs Oudkerk |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2003-03-17 |
Journal Detail:
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Title: Circulation Volume: 107 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-01 Completed Date: 2003-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 1592-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University Hospital Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands. kps@xs4all.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Angiography Disease-Free Survival Dobutamine / diagnostic use* Female Heart / physiology Humans Magnetic Resonance Imaging / methods* Male Middle Aged Motion Myocardial Ischemia / diagnosis*, mortality, radiography Survival Rate |
| Chemical | |
Reg. No./Substance:
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34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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