Document Detail

Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: an effect reversed by thyroxine pretreatment.
MedLine Citation:
PMID:  12559376     Owner:  NLM     Status:  MEDLINE    
The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 microg/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 microg 100 g(-1) body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction.
Constantinos Pantos; Iordanis Mourouzis; Stylianos Tzeis; Panagiotis Moraitis; Vassiliki Malliopoulou; Demosthenis D Cokkinos; Hariclia Carageorgiou; Dennis Varonos; Dennis Cokkinos
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  460     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Department of Pharmacology, University of Athens, 75 Mikras Asias Avenue, 11527 Goudi, Athens, Greece.
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MeSH Terms
Cardiotonic Agents / adverse effects,  pharmacology*
Dobutamine / adverse effects,  pharmacology*
Heart / drug effects*,  physiology,  physiopathology
Heart Ventricles / drug effects,  physiopathology
Myocardial Ischemia / complications
Myocardial Reperfusion Injury / etiology,  physiopathology,  prevention & control*
Propranolol / pharmacology
Thyroxine / pharmacology*
Time Factors
Ventricular Function
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine; 525-66-6/Propranolol; 7488-70-2/Thyroxine

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