| Do we still need to collect stool? Evaluation of visualized fatty acid absorption: experimental studies using rats. | |
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MedLine Citation:
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PMID: 9437650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Short-gut syndrome is likely to impair enteric fat utilization. This study was undertaken to develop a clinical test of lipid absorption without fecal collection. METHODS: The absorption of enterally fed radioactive long-chain fatty acid, beta-methyl-p-(123I)-iodophenylpentadecanoic acid was investigated with continuous chyle collection in rats. The changes in excretion and time-dependent biodistribution of radioactivity of the enterally fed agent were assessed in normal control animals. Similarly, sequential urinary excretion and biodistribution were studied along with scintigraphy using sham-operated and short-gut animals. RESULTS: Approximately 64% of the enterally fed radioactivity was recovered in the collected chyle (24 hours). A comparison of normal control, sham-operated, and short-gut animals showed significantly less urinary and greater fecal excretions of radioactivity in short-gut animals. With the use of sequential scintigraphy, the small intestine, whole-body soft tissues, and urinary bladder were well visualized in sham-operated animals, whereas the large intestine and feces were demonstrated earlier in short-gut animals. CONCLUSIONS: Our results suggest that enteral feeding of the agent might be feasible for determining lipid absorption from the the dynamic changes of radioactivity in visualized abdominal organs and in urine. |
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Authors:
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T Chiba; R Ohi |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 22 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1998 Jan-Feb |
Date Detail:
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Created Date: 1998-02-17 Completed Date: 1998-02-17 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 22-6 Citation Subset: IM |
Affiliation:
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Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Chyle / chemistry* Enteral Nutrition / methods* Fatty Acids / administration & dosage, blood, pharmacokinetics*, urine Female Intestinal Absorption Intestines / chemistry Iodine Radioisotopes / diagnostic use Iodobenzenes / administration & dosage, blood, pharmacokinetics*, urine Lipid Metabolism* Liver / chemistry Rats Rats, Sprague-Dawley Short Bowel Syndrome / pathology* Stomach / chemistry Time Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 116754-87-1/iodofiltic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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