Document Detail

Do we have suitable in-vitro diagnostic tests for the diagnosis of food allergy?
MedLine Citation:
PMID:  15126944     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Positive standardized food challenges represent the gold standard of diagnostic procedures in food-related reactions suspected to be of allergic nature. Skin prick testing and in-vitro diagnosis is helpful in most cases and can help to avoid cumbersome food challenges. This review considers recent progress in the use of in-vitro tests in the diagnosis of food allergy. RECENT FINDINGS: Recent studies have addressed the characterization of 'new' food allergens which might now be used more accurately in the in-vitro diagnosis of food allergy. Additionally, while in-vitro tests must always be interpreted in line with the allergen tested and the clinical history, levels of food-specific immunoglobulin E can be correlated with the outcome of challenges to foods such as tree nuts as well as egg, according to two recent studies. Finally, epitope binding patterns of specific food allergens might help to predict which patients will most likely outgrow their food allergy, or which patients are clinically tolerant. This might help to avoid food challenges, which carry a risk for a potentially severe outcome. SUMMARY: Recent studies of in-vitro diagnosis of food allergy have helped to provide safer and more accurate tests in the diagnosis and prognosis of food allergy.
Philippe A Eigenmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  4     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-05     Completed Date:  2004-12-02     Revised Date:  2010-10-20    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-3     Citation Subset:  IM    
Pediatric Allergy, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.
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MeSH Terms
Antigens, CD / blood
Food Hypersensitivity / blood,  diagnosis*,  immunology*
Immune Tolerance
Immunoglobulin E / blood
Immunologic Tests / methods
Platelet Membrane Glycoproteins
Predictive Value of Tests
Sensitivity and Specificity
Reg. No./Substance:
0/Antigens, CD; 0/CD63 antigen; 0/Platelet Membrane Glycoproteins; 37341-29-0/Immunoglobulin E

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