| Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block? | |
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MedLine Citation:
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PMID: 21305570 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? Methods: We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was measured at weeks 2 and 18 using the Appel Amyotrophic Lateral Sclerosis (AALS) score (includes grip and pincer strength measures), ALS Functional Rating Scale (ALSFRS), and electrophysiological measures, including motor unit estimates (MUNEs). Results: No change occurred in AALS or ALSFRS scores posttreatment. Grip/pincer strength increased in 7 patients (P = 0.028) after initial treatment (responders); 2 showed no improvement (non-responders). No electrophysiological measure changed after treatment in either group but MUNEs trended higher (P = 0.055). "Abnormal A-waves" (complex, repetitive biphasic, or present in multiple nerves) occurred in pretreatment studies more often in responders (P = 0.028).Discussion:"Abnormal A-waves" may signal IVIg-responsive LMN syndromes even if conduction block is absent. Muscle Nerve, 2011. |
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Authors:
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Dale J Lange; Rajwinder Nijjar; Andrei Voustianiouk; Gregory Seidel; Janki Panchal; Annabel K Wang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
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Title: Muscle & nerve Volume: - ISSN: 1097-4598 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Neurology, Division of Neuromuscular Disease, Mount Sinai School of Medicine, New York, New York, USA. langed@hss.edu. |
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