Document Detail

Do substantia nigra dopaminergic neurons differentiate between reward and punishment?
MedLine Citation:
PMID:  19770170     Owner:  NLM     Status:  MEDLINE    
The activity of dopaminergic neurons are thought to be increased by stimuli that predict reward and decreased by stimuli that predict aversive outcomes. Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of dopaminergic neurons in the substantia nigra pars compacta.
Michael J Frank; D James Surmeier
Publication Detail:
Type:  Journal Article     Date:  2009-09-21
Journal Detail:
Title:  Journal of molecular cell biology     Volume:  1     ISSN:  1759-4685     ISO Abbreviation:  J Mol Cell Biol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-02-18     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  101503669     Medline TA:  J Mol Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-6     Citation Subset:  IM    
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MeSH Terms
Conditioning (Psychology) / physiology
Dopamine / metabolism*
Haplorhini / physiology
Neurons / physiology*
Substantia Nigra / physiology*
Reg. No./Substance:

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