Document Detail


Do statins reduce blood pressure?: a meta-analysis of randomized, controlled trials.
MedLine Citation:
PMID:  17309949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A meta-analysis was performed of the effect of 3hydroxy3methylglutaryl-coenzyme A reductase inhibitors (statins) on blood pressure in humans including the randomized, controlled trials of statin therapy (20 trials and 828 patients) in which concomitant antihypertensive treatment (if any) remained unchanged throughout the study. A total of 291 and 272 patients were given a statin or placebo, respectively, in parallel group trials, whereas 265 took part in crossover trials receiving a statin and placebo (or probucol, in 1 trial). Systolic blood pressure was significantly lower in patients on statin than in those on placebo or control hypolipidemic drug (mean difference: -1.9 mm Hg; 95% CI: -3.8 to -0.1). The effect was greater when the analysis was restricted to studies with a baseline systolic blood pressure >130 mm Hg (Delta systolic blood pressure: -4.0; 95% CI: -5.8 to -2.2 mm Hg). There was a trend for lower diastolic blood pressure in patients receiving statin therapy compared with control: -0.9 mm Hg (95% CI: -2.0 to 0.2) overall and -1.2 mm Hg (95% CI: -2.6 to 0.1) in studies with a baseline diastolic blood pressure >80 mm Hg. In general, the higher the baseline blood pressure, the greater the effect of statins on blood pressure (P=0.066 for systolic blood pressure and P=0.023 for diastolic blood pressure). The blood pressure response to statins was unrelated to age, changes in serum cholesterol, or length of the trial. In conclusion, statin therapy has a relatively small but statistically significant and clinically meaningful effect on blood pressure.
Authors:
Pasquale Strazzullo; Sally M Kerry; Antonio Barbato; Marco Versiero; Lanfranco D'Elia; Francesco P Cappuccio
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2007-02-19
Journal Detail:
Title:  Hypertension     Volume:  49     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  792-8     Citation Subset:  IM    
Affiliation:
Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy. strazzul@unina.it
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Diastole
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hypertension / drug therapy*,  physiopathology*
Randomized Controlled Trials as Topic
Systole
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Comments/Corrections
Comment In:
Hypertension. 2007 Sep;50(3):e67; author reply e68   [PMID:  17664393 ]
Hypertension. 2007 Aug;50(2):e12; author reply e13   [PMID:  17562970 ]
Hypertension. 2007 Jun;49(6):e43; author reply e44   [PMID:  17404175 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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