| Do statins prevent heart failure in patients after myocardial infarction? | |
MedLine Citation:
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PMID: 16036039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, reduce morbidity and mortality in patients with coronary artery disease (CAD). Because CAD is the major cause of heart failure (HF) in developed countries, prevention of CAD may result in reduced HF. Evidence from randomized trials on lipid reduction (Cholesterol and Recurrent Events and the Scandinavian Simvastatin Survival Study) has shown statins to decrease progression to HF. Recently, many beneficial effects of statins have been demonstrated beyond cholesterol lowering. These agents improve endothelial function, exhibit anti-inflammatory properties, and prevent cardiac hypertrophy. Experimental studies have shown attenuation of left ventricular remodeling after myocardial infarction, possibly through reduced oxidative stress. However, no clinical evidence exists to support an effect on ventricular remodeling. Small, short-lasting clinical studies have also suggested that statin therapy might be associated with improved survival in ischemic and nonischemic HF. |
Authors:
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Anique Ducharme; Jean Lucien Rouleau |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current heart failure reports Volume: 1 ISSN: 1546-9530 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-07-22 Completed Date: 2005-10-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
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Languages: eng Pagination: 156-60 Citation Subset: IM |
Affiliation:
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Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada. ducharme@icm.umontreal.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System Diseases / etiology Coronary Disease / blood, drug therapy Heart Failure / etiology, prevention & control* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hyperlipidemias / drug therapy Myocardial Infarction / complications* Neovascularization, Physiologic / drug effects Randomized Controlled Trials as Topic Ventricular Remodeling / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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