Document Detail


Do statins prevent heart failure in patients after myocardial infarction?
MedLine Citation:
PMID:  16036039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, reduce morbidity and mortality in patients with coronary artery disease (CAD). Because CAD is the major cause of heart failure (HF) in developed countries, prevention of CAD may result in reduced HF. Evidence from randomized trials on lipid reduction (Cholesterol and Recurrent Events and the Scandinavian Simvastatin Survival Study) has shown statins to decrease progression to HF. Recently, many beneficial effects of statins have been demonstrated beyond cholesterol lowering. These agents improve endothelial function, exhibit anti-inflammatory properties, and prevent cardiac hypertrophy. Experimental studies have shown attenuation of left ventricular remodeling after myocardial infarction, possibly through reduced oxidative stress. However, no clinical evidence exists to support an effect on ventricular remodeling. Small, short-lasting clinical studies have also suggested that statin therapy might be associated with improved survival in ischemic and nonischemic HF.
Authors:
Anique Ducharme; Jean Lucien Rouleau
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  1     ISSN:  1546-9530     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Affiliation:
Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada. ducharme@icm.umontreal.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System Diseases / etiology
Coronary Disease / blood,  drug therapy
Heart Failure / etiology,  prevention & control*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipidemias / drug therapy
Myocardial Infarction / complications*
Neovascularization, Physiologic / drug effects
Randomized Controlled Trials as Topic
Ventricular Remodeling / drug effects
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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