Document Detail


Do statins lower blood pressure?
MedLine Citation:
PMID:  17562781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypercholesterolemia is present in many patients with hypertension and adds a significant component of cardiovascular risk. The 3-hydroxy-3 methyl-glutarylcoenzyme A reductase inhibitors (statins) lower low-density lipoprotein cholesterol but also inhibit many of the structural and functional components of the arteriosclerotic process. Structural effects include reductions in vascular smooth muscle hypertrophy and proliferation, fibrin deposition, and collagen cross-linking. Among the functional effects are improvements in endothelial function, reduction in inflammatory cytokines and reactive oxygen species, and down-regulation of angiotensin II and endothelin receptors. These would be expected to reduce blood pressure in patients with hypertension; 14 studies have shown statin-induced decrease in blood pressure, but 11 studies showed no effect. Many of the studies had no placebo controls, were of short duration, or had small sample sizes, or combinations of these. Despite predictions made on the basis of the vasoprotective actions of statins, the blood-pressure-lowering effects of statins are at best modest.
Authors:
Simardeep Mangat; Sanjay Agarwal; Clive Rosendorff
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology and therapeutics     Volume:  12     ISSN:  1074-2484     ISO Abbreviation:  J. Cardiovasc. Pharmacol. Ther.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-12     Completed Date:  2007-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9602617     Medline TA:  J Cardiovasc Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-23     Citation Subset:  IM    
Affiliation:
Department of Medicine, Mount Sinai School of Medicine, New York, and the James J. Peters VA Medical Center, Bronx, New York 10468, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antilipemic Agents / pharmacology*
Arteriosclerosis / drug therapy,  physiopathology
Blood Pressure / drug effects*
Cholesterol, LDL / drug effects,  metabolism*
Clinical Trials as Topic
Endothelium, Vascular / drug effects,  physiopathology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Hypercholesterolemia / drug therapy,  physiopathology
Hypertension / drug therapy*
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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