Document Detail

Do statins improve heart failure outcome in post-myocardial infarction patients with moderate to severe left ventricular dysfunction?
MedLine Citation:
PMID:  20662872     Owner:  NLM     Status:  MEDLINE    
The authors conducted this retrospective cohort study to assess the influence of statins on heart failure (HF) outcome by enrolling 500 consecutive acute myocardial infarction patients, majority (339 of 500) with moderate to severe left ventricular dysfunction (ejection fraction <40%) between March 2000 and March 2002 with 5.5-year mean follow-up. They were retrospectively analyzed according to whether they were discharged on a statin, and their HF outcome was evaluated independent of overt clinical ischemic events. Mortality in the statin group was 71 of 249 (28.5%; median survival 252 days) vs 48 of 90 (53%; median survival, 141.5 days; P<.001) in the no-statin group. Univariate analysis showed fewer HF readmissions (statin group, 7% vs no-statin group, 32%; P<.001) and HF deaths (statin group, 4% vs no-statin group, 13%; P=.002). Multivariate analysis by logistic regression showed that these effects due to statins are independent of cholesterol levels, age, sex, drugs, revascularization, and implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy. Statins have an important role in independently improving HF outcome in post-myocardial infarction patients with left ventricular ejection fraction < 40%.
Rajiv Sankaranarayanan; Sameer Maini; Michael Anthony James; Stephanie Burtchaell; Amit K Chatterjee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  16     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-28     Completed Date:  2011-06-02     Revised Date:  2011-10-19    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  IM    
Copyright Information:
2010 Wiley Periodicals, Inc.
Manchester Heart Centre, UK.
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MeSH Terms
Great Britain
Heart Failure / drug therapy*,  mortality,  prevention & control
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hypolipidemic Agents / therapeutic use*
Kaplan-Meier Estimate
Logistic Models
Multivariate Analysis
Myocardial Infarction / complications,  drug therapy*,  mortality
Retrospective Studies
Severity of Illness Index
Statistics as Topic
Time Factors
Treatment Outcome
Ventricular Dysfunction, Left / physiopathology*
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Hypolipidemic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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