| Do statins improve heart failure outcome in post-myocardial infarction patients with moderate to severe left ventricular dysfunction? | |
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MedLine Citation:
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PMID: 20662872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors conducted this retrospective cohort study to assess the influence of statins on heart failure (HF) outcome by enrolling 500 consecutive acute myocardial infarction patients, majority (339 of 500) with moderate to severe left ventricular dysfunction (ejection fraction <40%) between March 2000 and March 2002 with 5.5-year mean follow-up. They were retrospectively analyzed according to whether they were discharged on a statin, and their HF outcome was evaluated independent of overt clinical ischemic events. Mortality in the statin group was 71 of 249 (28.5%; median survival 252 days) vs 48 of 90 (53%; median survival, 141.5 days; P<.001) in the no-statin group. Univariate analysis showed fewer HF readmissions (statin group, 7% vs no-statin group, 32%; P<.001) and HF deaths (statin group, 4% vs no-statin group, 13%; P=.002). Multivariate analysis by logistic regression showed that these effects due to statins are independent of cholesterol levels, age, sex, drugs, revascularization, and implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy. Statins have an important role in independently improving HF outcome in post-myocardial infarction patients with left ventricular ejection fraction < 40%. |
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Authors:
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Rajiv Sankaranarayanan; Sameer Maini; Michael Anthony James; Stephanie Burtchaell; Amit K Chatterjee |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 16 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2011-06-02 Revised Date: 2011-10-19 |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: IM |
Copyright Information:
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2010 Wiley Periodicals, Inc. |
Affiliation:
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Manchester Heart Centre, UK. rajiv-s@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Great Britain Heart Failure / drug therapy*, mortality, prevention & control Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypolipidemic Agents / therapeutic use* Kaplan-Meier Estimate Logistic Models Male Multivariate Analysis Myocardial Infarction / complications, drug therapy*, mortality Retrospective Studies Severity of Illness Index Statistics as Topic Time Factors Treatment Outcome Ventricular Dysfunction, Left / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Hypolipidemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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