Document Detail

Do sensory neurons mediate adaptive cytoprotection of gastric mucosa against bile acid injury?
MedLine Citation:
PMID:  1733359     Owner:  NLM     Status:  MEDLINE    
Pretreatment with the mild irritant 1 mmol acidified taurocholate protects the gastric mucosa from the injury induced by the subsequent application of 5 mmol acidified taurocholate, a phenomenon referred to as "adaptive cytoprotection." How this occurs remains an enigma. The purpose of this study was to investigate the role of sensory neurons and mucus secretion in this phenomenon. Prior to injury with 5 mmol acidified taurocholate (pH 1.2), the stomachs of six groups of rats were subjected to the following protocol. Two groups were topically pretreated with either saline or the mild irritant 1 mmol acidified taurocholate. Two other groups received the topical anesthetic 1% lidocaine prior to pretreatment with either saline or 1 mmol acidified taurocholate. The last two groups got the mucolytic agent 10% N-acetylcysteine (NAC) after pretreatment with either saline or 1 mmol acidified taurocholate. Injury was assessed by measuring net transmucosal ion fluxes, luminal appearance of deoxyribonucleic acid (DNA), and gross and histologic injury. Pretreatment with the mild irritant 1 mmol acidified taurocholate significantly decreased bile acid-induced luminal ion fluxes and DNA accumulation, suggesting mucosal protection (corroborated by gross and histologic injury analysis). This effect was negated by lidocaine but not by NAC. Thus, it appears that sensory neurons, and not increased mucus secretion, play a critical role in adaptive cytoprotection.
D W Mercer; W P Ritchie; D T Dempsey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  163     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-25     Completed Date:  1992-02-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12-7; discussion 17-8     Citation Subset:  AIM; IM    
Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
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MeSH Terms
Acetylcysteine / pharmacology
Adaptation, Physiological / physiology
Bile Acids and Salts / adverse effects*
DNA / metabolism
Gastric Mucosa / drug effects,  physiology*
Lidocaine / pharmacology
Mucus / secretion
Neurons, Afferent / physiology*
Rats, Inbred Strains
Taurocholic Acid / adverse effects
Reg. No./Substance:
0/Bile Acids and Salts; 137-58-6/Lidocaine; 616-91-1/Acetylcysteine; 81-24-3/Taurocholic Acid; 9007-49-2/DNA

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