Document Detail

Do risk factors for persistent asthma modify lung function in infants and young children with recurrent wheeze?
MedLine Citation:
PMID:  20672359     Owner:  NLM     Status:  MEDLINE    
SUMMARY BACKGROUND: There is very limited information on how the risk of persistent asthma in recurrent wheezing (RW) infants modifies their lung function early in life. The aim of this study is to compare lung function of RW infants and young children with a positive or negative asthma predictive index (API), an index previously used to anticipate asthma persistence into childhood and adolescence.
METHODS: Two groups of RW infants and young children were recruited in two centres in Spain (Palma de Mallorca and Murcia). Lung function was measured according to the thoracho-abdominal compression technique (RCT), and values of the maximal flow at functional residual capacity (V'FRC) were expressed as Z-scores. Other variables included in the study, as independent factors, were: gender, age, length, weight, and parental smoking habits together with information regarding API.
RESULTS: Expressed as mean +/- SD, API+ RW infants (n = 50; age in months 11.9 +/- 4.9) had a lower V'FRC Z-score than API- RW ones (n = 41; age in months 12.3 +/- 6.2; -2.01 +/- 0.79 vs. -1.64 +/- 0.77, P = 0.026, respectively). Centre and tobacco exposition did not have an effect on lung function.
CONCLUSION: Among RW infants and young children, those having a positive API have a significant lower lung function as measured by V'FRC at an early age.
Esteban Keklikian; Manuel Sanchez-Solis; Angel Jose Bonina; Alejandra Meneguzzi; Maria Dolores Pastor-Vivero; Pedro Mondejar-Lopez; Luis Garcia-Marcos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  45     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  914-8     Citation Subset:  IM    
Paediatric Pulmonology Unit, Paediatric Department, Palmaplanas Clinic, Palma de Mallorca, Spain.
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MeSH Terms
Asthma / diagnosis*,  physiopathology*
Functional Residual Capacity
Lung / physiopathology*
Respiratory Mechanics / physiology*
Respiratory Sounds / physiopathology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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