Document Detail

Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide.
MedLine Citation:
PMID:  11248357     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions. Rat pups were exposed to single or multiple hyperthermic seizures. Subconvulsant doses of pilocarpine (100 mg/kg and 150 mg/kg) were injected intraperitoneally to these rats at 60--70 days of age. Also L-arginine was applied to some rats before a single hyperthermic seizure. We found that risk of future epilepsy increases parallel to the number of febrile convulsions and nitric oxide does not have a pathogenetic role at given doses.
G Gulec; B Noyan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  126     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
Uludag University Medical Faculty, Department of Physiology, 16059 Görükle, Bursa, Turkey.
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MeSH Terms
Arginine / administration & dosage
Behavior, Animal
Body Temperature / drug effects
Disease Models, Animal
Disease Progression
Disease Susceptibility / metabolism,  physiopathology
Dose-Response Relationship, Drug
Electroencephalography / drug effects
Epilepsy, Temporal Lobe / etiology,  physiopathology*
Hyperthermia, Induced / adverse effects
Injections, Intraperitoneal
Nitric Oxide / metabolism
Rats, Wistar
Reaction Time / drug effects
Risk Assessment
Seizures / chemically induced*,  physiopathology*
Seizures, Febrile / metabolism,  physiopathology*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 74-79-3/Arginine; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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