Document Detail

Do randomized trials of thrombolysis versus open revascularization still apply to current management: what has changed?
MedLine Citation:
PMID:  19298935     Owner:  NLM     Status:  MEDLINE    
Several randomized trials of catheter-directed thrombolysis versus operative revascularization in patients with acute lower extremity ischemia were performed in the mid-1990 s. Although the outcomes of these trials were not definitive, they did provide insight into potential uses and techniques of catheter-directed thrombolysis and lytic agents. This article reviews the outcomes of these randomized trials and describes advances in thrombolytic techniques and technology, including percutaneous mechanical thrombectomy devices and innovative catheter designs that accelerate lysis and the development of direct-acting lytic agents.
Anthony J Comerota; Marilyn H Gravett
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in vascular surgery     Volume:  22     ISSN:  1558-4518     ISO Abbreviation:  Semin Vasc Surg     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809602     Medline TA:  Semin Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
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MeSH Terms
Acute Disease
Combined Modality Therapy
Equipment Design
Evidence-Based Medicine
Fibrinolytic Agents / administration & dosage*,  adverse effects
Hospital Mortality
Ischemia / drug therapy,  mortality,  radiography,  surgery,  therapy*
Limb Salvage
Lower Extremity / blood supply*
Randomized Controlled Trials as Topic*
Thrombectomy* / adverse effects,  instrumentation,  mortality
Thrombolytic Therapy* / adverse effects,  instrumentation,  mortality
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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