| Do randomized trials of thrombolysis versus open revascularization still apply to current management: what has changed? | |
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MedLine Citation:
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PMID: 19298935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several randomized trials of catheter-directed thrombolysis versus operative revascularization in patients with acute lower extremity ischemia were performed in the mid-1990 s. Although the outcomes of these trials were not definitive, they did provide insight into potential uses and techniques of catheter-directed thrombolysis and lytic agents. This article reviews the outcomes of these randomized trials and describes advances in thrombolytic techniques and technology, including percutaneous mechanical thrombectomy devices and innovative catheter designs that accelerate lysis and the development of direct-acting lytic agents. |
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Authors:
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Anthony J Comerota; Marilyn H Gravett |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in vascular surgery Volume: 22 ISSN: 1558-4518 ISO Abbreviation: Semin Vasc Surg Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809602 Medline TA: Semin Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 41-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Michigan, Ann Arbor, MI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amputation Combined Modality Therapy Equipment Design Evidence-Based Medicine Fibrinolytic Agents / administration & dosage*, adverse effects Hospital Mortality Humans Ischemia / drug therapy, mortality, radiography, surgery, therapy* Limb Salvage Lower Extremity / blood supply* Randomized Controlled Trials as Topic* Thrombectomy* / adverse effects, instrumentation, mortality Thrombolytic Therapy* / adverse effects, instrumentation, mortality Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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