Document Detail

Do pregnancies with pre-eclampsia have smaller placentas? A population study of 317 688 pregnancies with and without growth restriction in the offspring.
MedLine Citation:
PMID:  20840528     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study whether placental weight is related to pre-eclampsia risk, independent of offspring birthweight.
DESIGN: Registry study.
SETTING: Medical Birth Registry of Norway.
POPULATION: All singleton pregnancies in Norway from 1999 to 2004, 317 688 births.
METHODS: Placental weight was grouped into deciles of placental weight z-scores. The proportion of pregnancies in each placental weight decile was calculated by maternal pre-eclampsia status for pregnancies with and without small-for-gestational-age (SGA) offspring.
MAIN OUTCOME MEASURES: Pre-eclampsia risk (proportions and odds ratios) according to placental weight.
RESULTS: In pregnancies with SGA offspring, approximately 60% of pregnancies were in the lowest decile of placental weight, 59.9% in pregnancies with and 61.4% in pregnancies without pre-eclampsia. Pregnancies without SGA offspring were evenly distributed across placental weight deciles, but were slightly higher in the lowest (9.5% versus 8.5%) and highest (11.9% versus 10.2%) deciles in pre-eclamptic pregnancies compared with pregnancies without pre-eclampsia. A weak U-shaped association of placental weight with pre-eclampsia was also estimated as odds ratios in pregnancies with SGA, but not without SGA, in the offspring.
CONCLUSIONS: Placental weight is linked to the offspring's birthweight, but is not clearly associated with pre-eclampsia risk, suggesting that placental weight is not a useful indicator for the placental dysfunction in pre-eclampsia.
A Eskild; L J Vatten
Related Documents :
4143538 - Contribution of fetal/maternal incompatibility to aetiology of pre-eclamptic toxaemia.
17877438 - The safety of pharmacological therapies for gastrointestinal conditions encountered dur...
2547468 - Efficacy and long term effects of antenatal prophylaxis with anti-d immunoglobulin.
11821338 - Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk. a s...
10486478 - Anti-beta2-glycoprotein i antibodies in women with recurrent spontaneous abortion, unex...
12738128 - Fetal sex determination from maternal blood at 6 weeks of gestation when at risk for 21...
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2010-09-14
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  117     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1521-6     Citation Subset:  AIM; IM    
Copyright Information:
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.
Department of Obstetrics and Gynaecology and Medical Faculty Division, Akershus University Hospital, Lørenskog, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fetal Growth Retardation / pathology*
Infant, Newborn
Infant, Small for Gestational Age*
Organ Size
Placenta / pathology*
Pre-Eclampsia / pathology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Proportion of excision and cervical healing after large loop excision of the transformation zone for...
Next Document:  The impact of mode of anaesthesia on postoperative recovery from fast-track abdominal hysterectomy: ...