| Do pregnancies with pre-eclampsia have smaller placentas? A population study of 317 688 pregnancies with and without growth restriction in the offspring. | |
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MedLine Citation:
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PMID: 20840528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study whether placental weight is related to pre-eclampsia risk, independent of offspring birthweight. DESIGN: Registry study. SETTING: Medical Birth Registry of Norway. POPULATION: All singleton pregnancies in Norway from 1999 to 2004, 317 688 births. METHODS: Placental weight was grouped into deciles of placental weight z-scores. The proportion of pregnancies in each placental weight decile was calculated by maternal pre-eclampsia status for pregnancies with and without small-for-gestational-age (SGA) offspring. MAIN OUTCOME MEASURES: Pre-eclampsia risk (proportions and odds ratios) according to placental weight. RESULTS: In pregnancies with SGA offspring, approximately 60% of pregnancies were in the lowest decile of placental weight, 59.9% in pregnancies with and 61.4% in pregnancies without pre-eclampsia. Pregnancies without SGA offspring were evenly distributed across placental weight deciles, but were slightly higher in the lowest (9.5% versus 8.5%) and highest (11.9% versus 10.2%) deciles in pre-eclamptic pregnancies compared with pregnancies without pre-eclampsia. A weak U-shaped association of placental weight with pre-eclampsia was also estimated as odds ratios in pregnancies with SGA, but not without SGA, in the offspring. CONCLUSIONS: Placental weight is linked to the offspring's birthweight, but is not clearly associated with pre-eclampsia risk, suggesting that placental weight is not a useful indicator for the placental dysfunction in pre-eclampsia. |
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Authors:
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A Eskild; L J Vatten |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2010-09-14 |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 117 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 1521-6 Citation Subset: AIM; IM |
Copyright Information:
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© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology. |
Affiliation:
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Department of Obstetrics and Gynaecology and Medical Faculty Division, Akershus University Hospital, Lørenskog, Norway. anne.eskild@medisin.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetal Growth Retardation / pathology* Humans Infant, Newborn Infant, Small for Gestational Age* Organ Size Placenta / pathology* Pre-Eclampsia / pathology* Pregnancy Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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