Document Detail

Do pre- and postchallenge small intestinal biopsies help to diagnose cow's milk protein intolerance?
MedLine Citation:
PMID:  575016     Owner:  NLM     Status:  MEDLINE    
Twelve infants suspected of cow's milk protein intolerance were challenged with cow's milk after at least one month of cow's milk-free diet. The challenge was clinically positive in seven. Small intestinal biopsies were taken with a multipurpose capsule both pre- and postchallenge (at 24 h) in eight, prechallenge in three, and postchallenge in one. Two or three biopsy specimens were taken at the same time in 15 of the 20 biopsy occasions. The morphology of the mucosa could vary from normal to slight damage at the same biopsy occasion. No difference was found in morphology judged by light microscopy between pre- and postchallenged biopsies. Light microscopy of small intestinal biopsies taken before and at 24 h after milk challenge seems of doubtful value as a routine diagnostic means in cow's milk protein intolerance.
N O Berg; I Jakobsson; T Lindberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  68     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Food Hypersensitivity / diagnosis,  pathology*
Intestinal Mucosa / pathology
Intestine, Small / pathology*
Milk / adverse effects
Milk Proteins / adverse effects*
Reg. No./Substance:
0/Milk Proteins

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