| Do placental lesions reflect thrombophilia state in women with adverse pregnancy outcome? | |
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MedLine Citation:
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PMID: 10920112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the relationship between placental histology and thrombophilia status in women who were admitted with severe pre-eclampsia/eclampsia, placental abruption, intrauterine growth restriction or unexplained stillbirth. All women had thrombophilia screen at least 10 weeks after delivery (antithrombin III, protein C, protein S, activated protein C resistance, anticardiolipin antibodies, lupus anticoagulant, fasting plasma homocysteine and specific mutations to methylenetetrahydrofolate reductase C677T, G20210A prothrombin gene and factor V Leiden. Placental histology reports were examined to identify the frequency of thrombotic lesions in the placenta including fetal stem vessel thrombosis, fetal thrombotic vasculopathy, placental infarction, perivillous fibrin deposition, intervillous thrombosis and placental floor infarction. During a 17 month period, a cohort of 79 women met the study criteria. Thirty (70%) out of 43 women with abnormal thrombophilia screen had abnormal placental histology. Twenty-eight (78%) out of 36 women with negative thrombophilia screen had abnormal placentae. No specific histological pattern could be identified when thrombophilia positive and thrombophilia negative groups were compared. We propose that there is a poor correlation between thrombophilia status and pathological changes of the placenta in women with severe pregnancy complications. |
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Authors:
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H A Mousa; Z Alfirevic1 |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 15 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-06 Completed Date: 2000-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1830-3 Citation Subset: IM |
Affiliation:
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University Department of Obstetrics and Gynaecology, Liverpool Women's Hospital, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Death Fetal Growth Retardation / pathology Humans Placenta / pathology* Pre-Eclampsia / pathology Pregnancy Pregnancy Complications / pathology Pregnancy Complications, Hematologic / pathology* Pregnancy Outcome* Thrombophilia / complications, diagnosis*, pathology* |
| Comments/Corrections | |
Comment In:
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Hum Reprod. 2001 Feb;16(2):395-7
[PMID:
11157843
]
Hum Reprod. 2001 Feb;16(2):395; author reply 397 [PMID: 11157844 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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