Document Detail


Do patients with schizophrenia exhibit aberrant salience?
MedLine Citation:
PMID:  18588739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It has been suggested that some psychotic symptoms reflect 'aberrant salience', related to dysfunctional reward learning. To test this hypothesis we investigated whether patients with schizophrenia showed impaired learning of task-relevant stimulus-reinforcement associations in the presence of distracting task-irrelevant cues.
METHOD: We tested 20 medicated patients with schizophrenia and 17 controls on a reaction time game, the Salience Attribution Test. In this game, participants made a speeded response to earn money in the presence of conditioned stimuli (CSs). Each CS comprised two visual dimensions, colour and form. Probability of reinforcement varied over one of these dimensions (task-relevant), but not the other (task-irrelevant). Measures of adaptive and aberrant motivational salience were calculated on the basis of latency and subjective reinforcement probability rating differences over the task-relevant and task-irrelevant dimensions respectively.
RESULTS: Participants rated reinforcement significantly more likely and responded significantly faster on high-probability-reinforced relative to low-probability-reinforced trials, representing adaptive motivational salience. Patients exhibited reduced adaptive salience relative to controls, but the two groups did not differ in terms of aberrant salience. Patients with delusions exhibited significantly greater aberrant salience than those without delusions, and aberrant salience also correlated with negative symptoms. In the controls, aberrant salience correlated significantly with 'introvertive anhedonia' schizotypy.
CONCLUSIONS: These data support the hypothesis that aberrant salience is related to the presence of delusions in medicated patients with schizophrenia, but are also suggestive of a link with negative symptoms. The relationship between aberrant salience and psychotic symptoms warrants further investigation in unmedicated patients.
Authors:
J P Roiser; K E Stephan; H E M den Ouden; T R E Barnes; K J Friston; E M Joyce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-30
Journal Detail:
Title:  Psychological medicine     Volume:  39     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-04-21     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-209     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological
Adolescent
Adult
Conditioning (Psychology)
Dopamine / physiology
Feedback
Female
Fixation, Ocular
Humans
Learning
Male
Middle Aged
Motivation
Psychological Tests
Psychotic Disorders / physiopathology,  psychology
Reaction Time
Reinforcement (Psychology)
Reward
Schizophrenia / physiopathology*
Schizophrenic Psychology
Young Adult
Grant Support
ID/Acronym/Agency:
064607//Wellcome Trust; 064607 /z/01/z//Wellcome Trust; 088130//Wellcome Trust
Chemical
Reg. No./Substance:
VTD58H1Z2X/Dopamine
Comments/Corrections
Comment In:
Psychol Med. 2009 Feb;39(2):197-8   [PMID:  18694541 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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