Document Detail


Do nutritional alterations contribute to adriamycin-induced impaired wound healing?
MedLine Citation:
PMID:  3411949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adriamycin-impaired wound healing in mice was found to be related to the degree of weight loss which in turn was dependent on the dose given. Treated animals had an initial decrease in food consumption that correlated with initial weight loss. After approximately 7 days, food consumption returned to normal but the weight loss persisted. Both Adriamycin-treated mice and animals pair fed the amount of food consumed by drug-treated mice had wounds significantly weaker than control animals at 7 and 11 days. The Adriamycin-treated animals had 11-day wound strengths equal to or weaker than the pair fed group. By Day 14, the pair fed animals had wounds similar to those of controls but the Adriamycin-treated animals remained significantly weaker than the other groups. We feel that initially Adriamycin produces a short-term nutritional deficit that contributes to early wound healing impairment. Later, the toxicity of the drug predominates in altering wound repair.
Authors:
D G Greenhalgh; R L Gamelli
Related Documents :
3559859 - The role of intraluminal tension and ph in the development of necrotizing enterocolitis...
3514089 - Nutrition and the pulmonary parenchyma.
12866569 - Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates.
19152769 - 311 risk analysis of alpha-lactalbumin transgene transfer to non-transgenic control ani...
15296179 - Reducing environmental pollution using animal feed enzymes.
24228189 - Resistant starch: promise for improving human health.
22082109 - Rapid successions affect microbial n-acetyl-glucosamine uptake patterns during a lacust...
11034579 - Heterogeneity of gastric histology and function in food cobalamin malabsorption: absenc...
25280419 - Estimated dietary intake and major food sources of polyphenols in the polish arm of the...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  45     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-07     Completed Date:  1988-10-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
Affiliation:
University of Washington, Department of Surgery, Seattle 98105.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Collagen / biosynthesis
Deficiency Diseases / chemically induced,  physiopathology*
Dose-Response Relationship, Drug
Doxorubicin / toxicity*
Eating / drug effects
Male
Mice
Motor Activity / drug effects
Tensile Strength
Wound Healing / drug effects*
Wounds and Injuries / metabolism
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Micromorphometry of colonic lesions.
Next Document:  Effect of antibody-mediated neutropenia on the cardiopulmonary response to endotoxemia.