Document Detail

Do non-steroidal anti-inflammatory drugs have a significant effect on detection and grading of ultrasound-detected synovitis in patients with rheumatoid arthritis? Results from a randomised study.
MedLine Citation:
PMID:  21803749     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether non-steroidal anti-inflammatory drugs (NSAIDs) have a significant effect on ultrasonographic (US) grey scale (GS) and power Doppler (PD) assessment of synovitis in rheumatoid arthritis (RA).
METHODS: Patients with RA taking NSAIDs were randomised to either stopping (for a minimum of 5 drug half-lives) or continuing the drug. All patients had a clinical assessment and US examination of both hands and wrists before and after stopping/continuing the NSAID. Changes at follow-up were compared between groups using Mann-Whitney U tests.
RESULTS: A total of 58 patients with RA were recruited. All the clinical assessment parameters (including disease activity, pain, general state of health and physician global visual analogue score and tender and swollen joints count) showed an increase in the group who stopped their NSAID treatment. The total GS and PD score showed median (first to third quartiles) increase of 9.5 (5.75 to 19.0) and 4.0 (2.0 to 6.0) per patient, respectively, in the patients who stopped their NSAID in comparison with 1.0 (-1.0 to 2.25) and 0.0 (-2.0 to 3.0), respectively, in the patients who continued their NSAID (p<0.001). There was an increase in the number of joints scoring >0 for GS and PD in the patients who stopped the NSAID. The inter- and intrareader agreement was good to excellent for the US examination.
CONCLUSION: NSAID usage may mask the GS and PD signal and result in lower scoring despite continuing disease activity. Consideration should be given to the NSAID effect in designing clinical studies which use US to assess response to therapeutic.
Ahmed S Zayat; Philip G Conaghan; Mohammad Sharif; Jane E Freeston; Claire Wenham; Elizabeth M A Hensor; Paul Emery; Richard J Wakefield
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-07-28
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  70     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-06     Completed Date:  2011-11-09     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1746-51     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology*,  therapeutic use
Arthritis, Rheumatoid / complications,  drug therapy*,  ultrasonography
Drug Administration Schedule
Follow-Up Studies
Hand Joints / ultrasonography
Middle Aged
Severity of Illness Index
Synovial Membrane / drug effects*,  ultrasonography
Synovitis / etiology,  ultrasonography*
Ultrasonography, Doppler / methods
Wrist Joint / ultrasonography
Young Adult
Grant Support
18475//Arthritis Research UK
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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