Document Detail


Do neurotrophins regulate the feto-placental development?
MedLine Citation:
PMID:  21377276     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Numerous data highlight the importance of a fine regulation of the fetal growth for the individual's subsequent susceptibility to diseases. Recent evidence suggests that neurotrophins may have important functions during pregnancy and that they could modulate fetal growth. We hypothesize that neurotrophins may participate in fetal growth by different pathways: (1) these molecules may participate in the development and the maturation of both central and peripheral fetal organs, including the placenta; (2) neurotrophins may constitute a link between the maternal nutrition and the fetal nutrients demand and thus could act as a nutrient sensor for the development and efficiency of the placenta; (3) maternal and placental neurotrophins may control the fetal development directly but also by activating the production and release of others growth factors. In conclusion, neurotrophins may participate to a new pathway controlling fetal growth and may be implicated, at least in part, under physiopathological conditions in disturbances of the fetal growth trajectory.
Authors:
Sylvain Mayeur; Marie Amélie Lukaszewski; Christophe Breton; Laurent Storme; Didier Vieau; Jean Lesage
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-3
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Université Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Equipe dénutritions maternelles périnatales, Université de Lille1, Bâtiment SN4, F-59655 Villeneuve d'Ascq, France.
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