Document Detail

Do neuroactive steroids cause fatigue in pregnancy?
MedLine Citation:
PMID:  7758639     Owner:  NLM     Status:  MEDLINE    
To elucidate factors causing widespread fatigue in pregnancy we studied plasma samples from 23 healthy pregnant volunteers, measuring endogenous neuroactive steroids, endozepines and benzodiazepines by receptor binding assays. The samples were taken at different gestational ages and the women were asked about their feeling of fatigue at the time of sample collection. We found a significant correlation between fatigue in pregnancy and presence of neuroactive steroid-like activity, but could not detect endogenous benzodiazepine-like factors. These results suggest that neuroactive steroids may be involved in fatigue during pregnancy. Their site of synthesis and their biological role remain unclear.
K Biedermann; P Schoch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  58     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-27     Completed Date:  1995-06-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  15-8     Citation Subset:  IM    
Department of Gynecology and Obstetrics, University Hospital, Zurich, Switzerland.
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MeSH Terms
Benzodiazepines / blood*
Carrier Proteins / blood,  physiology*
Diazepam Binding Inhibitor
Fatigue / blood,  etiology*
Pregnancy Complications / blood,  etiology*
Pregnanes / blood*
Reg. No./Substance:
0/Carrier Proteins; 0/Diazepam Binding Inhibitor; 0/Pregnanes; 12794-10-4/Benzodiazepines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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