Document Detail

Do monoamine-synthesizing cells constitute a complex network of oxygen sensors?
MedLine Citation:
PMID:  19846259     Owner:  NLM     Status:  MEDLINE    
Oxygen represents an essential molecule for organisms. Because of this, sophisticated systems of sensors have evolved to monitor oxygenation of tissues. We propose that monoamine-synthesizing cells represent an important part of this system. It is well known that the carotid body, which contains chromaffin cells, serves as a chemical sensor of blood oxygenation. Similarly, the activity of adrenal medullary chromaffin cells is increased during hypoxia. Moreover, neurons located in the central nervous system containing catecholamines, serotonin, and histamine are also sensitive to hypoxia. On the basis of this common sensitivity of monoamine-synthesizing cells to changes in oxygenation we propose the hypothesis that these cells constitute a widely distributed network of sensors that monitor oxygen levels. The role of monoamine-synthesizing cells in monitoring tissue oxygen supply during both physiological and pathological conditions is also discussed.
K Ondicova; B Mravec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-28
Journal Detail:
Title:  Medical hypotheses     Volume:  74     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Faculty of Medicine, Institute of Pathophysiology, Comenius University, Slovak Academy of Sciences, Bratislava, Slovakia.
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MeSH Terms
Biogenic Monoamines / biosynthesis*
Cell Communication / physiology*
Models, Biological*
Oxygen / metabolism*
Signal Transduction / physiology*
Reg. No./Substance:
0/Biogenic Monoamines; 7782-44-7/Oxygen

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