Document Detail


Do mitochondrial DNA fragments promote cancer and aging?
MedLine Citation:
PMID:  3197826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reactive oxygen species are important in carcinogenesis, diseases, and aging, probably through oxidative damage of DNA. Our understanding of this relationship at the molecular level is very sketchy. It has recently been found that in mitochondria oxidative DNA damage is particularly high and may not be repaired efficiently. I propose that oxidatively generated DNA fragments escape from mitochondria and become integrated into the nuclear genome. This may transform cells to a cancerous state. Time-dependent nuclear accumulation of mitochondrial DNA fragments may progressively change the nuclear information content and thereby cause aging. This proposal can be tested experimentally.
Authors:
C Richter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  241     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-25     Completed Date:  1989-01-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Laboratory of Biochemistry, Swiss Federal Institute of Technology, Zurich.
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MeSH Terms
Descriptor/Qualifier:
Aging / genetics*
Carcinogens
DNA Damage
DNA, Mitochondrial / genetics*
Humans
Neoplasms / genetics*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/DNA, Mitochondrial
Comments/Corrections
Comment In:
FEBS Lett. 1990 Jan 29;260(2):318   [PMID:  2298306 ]

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