Document Detail


Do men with mild erectile dysfunction have the same risk factors as the general erectile dysfunction clinical trial population?
MedLine Citation:
PMID:  20950304     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: • To compare the underlying risk for diseases associated with erectile dysfunction (ED; i.e. cardiovascular disease and diabetes) in a population of men with mild ED relative to a general ED clinical trial population.
PATIENTS AND METHODS: • Men enrolled in a randomized, double-blind placebo-controlled (DBPC) trial of sildenafil for the treatment of mild ED were compared with a database of men enrolled in 67 of the manufacturer's other DBPC sildenafil trials. • The main outcome measures were baseline demographics, comorbidities and concomitant medications.
RESULTS: • In both populations, most men were white, approximately one quarter were smokers, and most had an organic component to their ED etiology. • In the mild ED population (N= 176) versus the database population (N= 14 537), mean ±sd (range) age was 50 ± 12 (19-84) versus 55 ± 11 (18-89) years, body mass index was 29 ± 5 (20-48) versus 28 ± 5 (11-64) kg/m(2) and ED duration was 3.5 ± 3.2 (<1-18) versus 4.6 ± 4.7 (<1-45) years. • The prevalence of comorbidities associated with ED was similar (hypertension 26.1% (n= 46) vs 32.8%; diabetes mellitus 13.6% (n= 24) vs 22.1%; dyslipidemias 12.5% (n= 22) vs 11.7%; hypercholesterolemia 12.5% (n= 22) vs 9.5%; gastro-esophageal reflux disease 10.8% (n= 19) vs 6.0%; benign prostatic hyperplasia 9.7% (n= 17) vs 9.9%; depression 6.3% (n= 11) vs 5.6%; and anxiety 4.0% (n= 7) vs 1.6%), as was the rate of use of medications for those comorbidities.
CONCLUSIONS: • Men with mild ED have similar risk factors to a general ED clinical trial population. Thus, mild ED is an important indicator of risk for underlying disease associated with ED. • Inquiry into ED should be part of routine clinical evaluation to facilitate rapid identification and early intervention. • Men complaining of mild ED should be evaluated adequately for underlying cardiovascular risk.
Authors:
Jay C Lee; Francois Bénard; Serge Carrier; Varun Talwar; Isabelle Defoy
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Publication Detail:
Type:  Journal Article     Date:  2010-10-15
Journal Detail:
Title:  BJU international     Volume:  107     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  956-60     Citation Subset:  IM    
Copyright Information:
© 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL.
Affiliation:
Rockyview Hospital, Calgary, AB, CHUM-St-Luc HospitalJewish General Hospital, McGill University, Montreal, QC, CanadaSciformix Technologies Pvt. Ltd, Mumbai, IndiaPfizer Canada Inc., Kirkland, QC, Canada.
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