| Do low vancomycine serum levels predict failures of vancomycine therapy in neutropenic cancer patients? | |
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MedLine Citation:
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PMID: 9117433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vancomycine serum levels were measured in 198 cancer patients with documented grampositive bacteremia and twenty two failed. Failures were analyzed for risk factors of therapy failure. Only 8 of 22 showed low serum peak or through vancomycin levels. One patient was treated less than 7 days, 9 had persisting and 4 catheter associated bacteremia. Bacteremias due to VAN resistant strains were excluded. In 14 out of 22 patients, multiple or one risk factor could be determined, but in 8 patients, no risk factor was found. Hence the, case control study was conducted to compare the group of failures in 22 patients with a group of patients with underlying disease and neutropenia treated successfully within the same period and same antibiotic policy at the same cancer center, by VAN for gram-positive bacteremia. Persisting, catheter associated and enterococcal bacteremias were the only statistical significant risk factors predicting a therapy failure in cancer patients. Neither Vancomycine serum peak nor through levels predicted the outcome: failure or cure of gram-positive bacteremia in cancer patients. (Tab. 1, Ref. 5.). |
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Authors:
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J Netriová; J Hal'ko; M Studená-Mrázová; E Kukucková; K Stopková; K Kral'ovicová; A Demitrovicová; S Grausová; I Krupová; J Trupl; V Krcméry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bratislavské lekárske listy Volume: 97 ISSN: 0006-9248 ISO Abbreviation: Bratisl Lek Listy Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0065324 Medline TA: Bratisl Lek Listy Country: SLOVAKIA |
Other Details:
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Languages: eng Pagination: 680-3 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, National Cancer Institute, Bratislava, Slovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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blood*,
therapeutic use Bacteremia / complications, drug therapy* Gram-Positive Bacterial Infections / complications, drug therapy* Humans Neoplasms / complications* Neutropenia / complications* Retrospective Studies Treatment Failure Vancomycin / blood*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 1404-90-6/Vancomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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