Document Detail

Do hormones influence melanoma? Facts and controversies.
MedLine Citation:
PMID:  20541681     Owner:  NLM     Status:  MEDLINE    
The issue of whether hormones influence malignant melanoma (MM) has been controversial for many years. Although early case reports demonstrated a negative effect of hormones, recent evidence has not supported a potential role for hormones in MM. We address whether exogenous and endogenous hormones influence a woman's risk for MM or affect her prognosis if diagnosed with MM. Multiple epidemiologic studies show the use of oral contraceptives or hormone replacement therapy does not appear to increase a woman's risk for MM. Pregnancy does not appear to influence a woman's risk of MM, nor does pregnancy appear to affect prognosis in the woman diagnosed with MM. When counseling the woman who is diagnosed with MM during pregnancy or during the childbearing years, future use of oral contraceptives or hormone replacement therapy is not contraindicated; counseling concerning future pregnancies should be done on a case-by-case basis, with emphasis placed on established prognostic factors for MM.
Amie Gupta; Marcia S Driscoll
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in dermatology     Volume:  28     ISSN:  1879-1131     ISO Abbreviation:  Clin. Dermatol.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406412     Medline TA:  Clin Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Dermatology, University of Maryland School of Medicine, 419 W Redwood St, Baltimore, MD 21201, USA.
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MeSH Terms
Contraceptives, Oral / adverse effects*
Directive Counseling
Hormone Replacement Therapy / adverse effects*
Hormones / adverse effects*,  physiology
Melanoma / chemically induced,  etiology*
Neoplasms, Hormone-Dependent / chemically induced,  etiology*
Pregnancy Complications, Neoplastic / chemically induced,  etiology*
Risk Factors
Skin Neoplasms / chemically induced,  etiology*
Reg. No./Substance:
0/Contraceptives, Oral; 0/Hormones

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