Document Detail

Do the high-frequency indexes of HRV provide a faithful assessment of cardiac vagal tone? A critical theoretical evaluation.
MedLine Citation:
PMID:  12814244     Owner:  NLM     Status:  MEDLINE    
When spectral analysis of the heart rate (HR) signal is performed, it is quite common to attribute the HF indexes of heart rate variability (HRV) to cardiac vagal control. The paradigm underlying this attribution states that changes in cardiac vagal outflow correspond to a proportional change in respiratory sinus arrhythmia (RSA). However, recent studies have demonstrated that variations in these indexes do not necessarily reflect proportional changes in vagal tone. The current study provides a theoretical evaluation of the relationship between mean HR, RSA, and cardiac vagal tone. This evaluation is based on a theoretical model, which quantifies the differential effects of vagal blockade by a competitive muscarinic antagonist on the HF indexes of HRV. The model relies on several assumptions that reflect the basic physiology of the sinoatrial (SA) node, as well as pharmacological relations that describe agonist/antagonist equilibrium at the SA receptors. The mathematical framework of this model is the integral-pulse-frequency-modulation (IPFM) process, and its derivations lead to a specific expressions for the dependence of HF and mean HR on the level of vagal blockade. These expressions provide a new insight into the relationship between mean HR, RSA, and vagal tone, and explain conflicting experimental results previously published.
Erez Pyetan; Solange Akselrod
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Validation Studies    
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  50     ISSN:  0018-9294     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-19     Completed Date:  2003-07-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-83     Citation Subset:  IM    
Abramson Center for Medical Physics, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
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MeSH Terms
Acetylcholine / metabolism
Arrhythmia, Sinus / physiopathology
Computer Simulation
Heart Rate / drug effects,  physiology*
Models, Cardiovascular*
Muscarinic Antagonists / pharmacology
Respiratory Physiological Phenomena
Sinoatrial Node / drug effects,  physiology*
Statistics as Topic
Synaptic Transmission / drug effects,  physiology
Vagus Nerve / drug effects,  physiology*
Reg. No./Substance:
0/Muscarinic Antagonists; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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