Document Detail


Do "heavy" eaters live longer?
MedLine Citation:
PMID:  18027392     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new hypothesis is put forward, linking cellular endurance with dietary consumption of stable heavy isotopes. Due to the isotope effect, biomolecules that incorporate heavier isotopes give rise to more stable molecular structures with increased resistance to damages associated with aging and age-related disease. The inclusion of heavy isotopes might be either active (selection for heavier isotopes) or passive (incorporation reflecting the existing abundance). The hypothesis links consumption of foods relatively rich in heavy isotopes (such as (13)C and D, derived from C4-plants), especially at the early stages of the organism's development, with enhanced longevity. Implications of diets and intestinal microflora are also discussed.
Authors:
Mikhail S Shchepinov
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  29     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-22     Completed Date:  2008-03-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1247-56     Citation Subset:  IM    
Copyright Information:
2007 Wiley Periodicals, Inc
Affiliation:
Retrotope Inc., 8 Barns Hay, Oxford, OX3 0PN, UK. misha@trdend.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Evolution
Feeding Behavior / physiology*
Gastrointestinal Tract / microbiology
Humans
Isotopes
Longevity / physiology*
Models, Biological*
Nutritional Physiological Phenomena
Chemical
Reg. No./Substance:
0/Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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